E-ISSN 0976-2779 | ISSN 0975-8453
 

Review Article 


Determination of Chemical Potential for Stavudine (D4T) Diffusion through SDS Micelle Solution

Jinan Abdul-Amir Sabeeh Al-Hussaini, Oraas Adnan Hatem, Zainab Adnan Hatem Alebady.

Abstract
This study include a spectroscopic measurements of Stavudine diffusion in cell membrane alternative model in two different polar solutions; buffer phosphate solution (Polar solution) and N-Hexane (Non-polar solution). Consistent with the standard values, a clear maximum absorption peaks at 266 nm was noted for Stavudine in buffer phosphate solution. The data also showed that the value of the extension coefficient and ÊŽmax reduced in the non-polar medium compare to polar medium which was noted a s a part of the spectroscopic properties of Stavudine in polar and non-polar medium. Stavudine express a high stability with time in pH 7.4 .
SDS was used as a cell membranes substitute model, and the diffusion rate of Stavudine through SDS micelles solution (with a concentration of 0.2 ×10-2 M)was examined. The chemical potential was calculated which was equal to -2489.4 J mol-1which indicate the impulsiveness of the diffusion process for the compound. The results suggested that Stavudine can diffuse (in a rate constant of 0.0183 min-1) to inside micelle from the aqueous medium. Of other detected factors; the equilibrium constant for diffusion rate was detected and was equal to 2.7313.

Key words: Stavudine, diffusion, SDS, micelle solution


 
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How to Cite this Article
Pubmed Style

Jinan Abdul-Amir Sabeeh Al-Hussaini, Oraas Adnan Hatem, Zainab Adnan Hatem Alebady. Determination of Chemical Potential for Stavudine (D4T) Diffusion through SDS Micelle Solution. SRP. 2020; 11(6): 96-100. doi:10.31838/srp.2020.6.17


Web Style

Jinan Abdul-Amir Sabeeh Al-Hussaini, Oraas Adnan Hatem, Zainab Adnan Hatem Alebady. Determination of Chemical Potential for Stavudine (D4T) Diffusion through SDS Micelle Solution. http://www.sysrevpharm.org//?mno=112584 [Access: June 05, 2020]. doi:10.31838/srp.2020.6.17


AMA (American Medical Association) Style

Jinan Abdul-Amir Sabeeh Al-Hussaini, Oraas Adnan Hatem, Zainab Adnan Hatem Alebady. Determination of Chemical Potential for Stavudine (D4T) Diffusion through SDS Micelle Solution. SRP. 2020; 11(6): 96-100. doi:10.31838/srp.2020.6.17



Vancouver/ICMJE Style

Jinan Abdul-Amir Sabeeh Al-Hussaini, Oraas Adnan Hatem, Zainab Adnan Hatem Alebady. Determination of Chemical Potential for Stavudine (D4T) Diffusion through SDS Micelle Solution. SRP. (2020), [cited June 05, 2020]; 11(6): 96-100. doi:10.31838/srp.2020.6.17



Harvard Style

Jinan Abdul-Amir Sabeeh Al-Hussaini, Oraas Adnan Hatem, Zainab Adnan Hatem Alebady (2020) Determination of Chemical Potential for Stavudine (D4T) Diffusion through SDS Micelle Solution. SRP, 11 (6), 96-100. doi:10.31838/srp.2020.6.17



Turabian Style

Jinan Abdul-Amir Sabeeh Al-Hussaini, Oraas Adnan Hatem, Zainab Adnan Hatem Alebady. 2020. Determination of Chemical Potential for Stavudine (D4T) Diffusion through SDS Micelle Solution. Systematic Reviews in Pharmacy, 11 (6), 96-100. doi:10.31838/srp.2020.6.17



Chicago Style

Jinan Abdul-Amir Sabeeh Al-Hussaini, Oraas Adnan Hatem, Zainab Adnan Hatem Alebady. "Determination of Chemical Potential for Stavudine (D4T) Diffusion through SDS Micelle Solution." Systematic Reviews in Pharmacy 11 (2020), 96-100. doi:10.31838/srp.2020.6.17



MLA (The Modern Language Association) Style

Jinan Abdul-Amir Sabeeh Al-Hussaini, Oraas Adnan Hatem, Zainab Adnan Hatem Alebady. "Determination of Chemical Potential for Stavudine (D4T) Diffusion through SDS Micelle Solution." Systematic Reviews in Pharmacy 11.6 (2020), 96-100. Print. doi:10.31838/srp.2020.6.17



APA (American Psychological Association) Style

Jinan Abdul-Amir Sabeeh Al-Hussaini, Oraas Adnan Hatem, Zainab Adnan Hatem Alebady (2020) Determination of Chemical Potential for Stavudine (D4T) Diffusion through SDS Micelle Solution. Systematic Reviews in Pharmacy, 11 (6), 96-100. doi:10.31838/srp.2020.6.17





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