E-ISSN 0976-2779 | ISSN 0975-8453
 

Review Article 


Molecular Markers in Diagnosis and Prognosis of Sepsis, Severe Sepsis and Septic Shock

Saad khalaf alrikabi, Hamidreza Fathi, Javad Rahmati.

Abstract
Background: Despite important advances in understanding the pathophysiology of sepsis, the mortality it generates remains high.
Objective: Describe the state of the art of molecular biomarkers proposed so far as potential markers for the diagnosis and prognosis of sepsis, severe sepsis and septic shock.
Results: The search yielded 3,370 references covering more than 30 genes with genetic polymorphisms that can be used as potential polymorphism markers. These were evaluated for its use in the different manifestations of sepsis, its diagnosis and progression. Twenty marker genes are described: four associated with bacteremia (TLR-1, TLR-2, Protein C and Selectin-E), nine with sepsis (IL-1B, IL-1A, IL-6, TNF-α, TLR-1, MBL-1, Hsp70, PAI-1 and MIF-1), seven with severe sepsis (IL-1RN, IL-10, TNF-α, CD14, TREM1, Caspasa 12 and DEFB-1), five with shock septic (TNF-B, TLR-4, Hsp70, MBL-1 and CD14) and three with dysfunction multi-organ (TLR-1, PAI-1 and Protein C).
Conclusion: Genetic polymorphisms, for the most part, have have been clinically proven as diagnostic markers and prognosis in sepsis with promising results due to discharge specificity and sensitivity in clinical practice.

Key words: Keywords: Sepsis; Biomarkers; Genetic polymorphism; Simple nucleotide polymorphism; Mini-satellite repeats (DeCS).


 
ARTICLE TOOLS
Abstract
PDF Fulltext
How to cite this articleHow to cite this article
Citation Tools
Related Records
 Articles by Saad khalaf alrikabi
Articles by Hamidreza Fathi
Articles by Javad Rahmati
on Google
on Google Scholar


How to Cite this Article
Pubmed Style

Saad khalaf alrikabi, Hamidreza Fathi, Javad Rahmati. Molecular Markers in Diagnosis and Prognosis of Sepsis, Severe Sepsis and Septic Shock. SRP. 2020; 11(6): 101-111. doi:10.31838/srp.2020.6.18


Web Style

Saad khalaf alrikabi, Hamidreza Fathi, Javad Rahmati. Molecular Markers in Diagnosis and Prognosis of Sepsis, Severe Sepsis and Septic Shock. http://www.sysrevpharm.org//?mno=112585 [Access: June 05, 2020]. doi:10.31838/srp.2020.6.18


AMA (American Medical Association) Style

Saad khalaf alrikabi, Hamidreza Fathi, Javad Rahmati. Molecular Markers in Diagnosis and Prognosis of Sepsis, Severe Sepsis and Septic Shock. SRP. 2020; 11(6): 101-111. doi:10.31838/srp.2020.6.18



Vancouver/ICMJE Style

Saad khalaf alrikabi, Hamidreza Fathi, Javad Rahmati. Molecular Markers in Diagnosis and Prognosis of Sepsis, Severe Sepsis and Septic Shock. SRP. (2020), [cited June 05, 2020]; 11(6): 101-111. doi:10.31838/srp.2020.6.18



Harvard Style

Saad khalaf alrikabi, Hamidreza Fathi, Javad Rahmati (2020) Molecular Markers in Diagnosis and Prognosis of Sepsis, Severe Sepsis and Septic Shock. SRP, 11 (6), 101-111. doi:10.31838/srp.2020.6.18



Turabian Style

Saad khalaf alrikabi, Hamidreza Fathi, Javad Rahmati. 2020. Molecular Markers in Diagnosis and Prognosis of Sepsis, Severe Sepsis and Septic Shock. Systematic Reviews in Pharmacy, 11 (6), 101-111. doi:10.31838/srp.2020.6.18



Chicago Style

Saad khalaf alrikabi, Hamidreza Fathi, Javad Rahmati. "Molecular Markers in Diagnosis and Prognosis of Sepsis, Severe Sepsis and Septic Shock." Systematic Reviews in Pharmacy 11 (2020), 101-111. doi:10.31838/srp.2020.6.18



MLA (The Modern Language Association) Style

Saad khalaf alrikabi, Hamidreza Fathi, Javad Rahmati. "Molecular Markers in Diagnosis and Prognosis of Sepsis, Severe Sepsis and Septic Shock." Systematic Reviews in Pharmacy 11.6 (2020), 101-111. Print. doi:10.31838/srp.2020.6.18



APA (American Psychological Association) Style

Saad khalaf alrikabi, Hamidreza Fathi, Javad Rahmati (2020) Molecular Markers in Diagnosis and Prognosis of Sepsis, Severe Sepsis and Septic Shock. Systematic Reviews in Pharmacy, 11 (6), 101-111. doi:10.31838/srp.2020.6.18





Most Viewed Articles
  • Dental Development between Assisted Reproductive Therapy (Art) and Natural Conceived Children: A Comparative Pilot Study
    Norzaiti Mohd Kenali, Naimah Hasanah Mohd Fathil, Norbasyirah Bohari, Ahmad Faisal Ismail, Roszaman Ramli
    SRP. 2020; 11(1): 01-06
    » Abstract » doi: 10.5530/srp.2020.1.01

  • Psychometric properties of the World Health Organization Quality of life instrument, short form: Validity in the Vietnamese healthcare context
    Trung Quang Vo*, Bao Tran Thuy Tran, Ngan Thuy Nguyen, Tram ThiHuyen Nguyen, Thuy Phan Chung Tran
    SRP. 2020; 11(1): 14-22
    » Abstract » doi: 10.5530/srp.2020.1.03

  • A Prospective Review on Phyto-Pharmacological Aspects of Andrographis paniculata
    Govindraj Akilandeswari, Arumugam Vijaya Anand, Palanisamy Sampathkumar, Puthamohan Vinayaga Moorthi, Basavaraju Preethi
    SRP. 2019; 10(1): 15-19
    » Abstract » doi: 10.5530/srp.2019.1.3

  • A Review of Pharmacoeconomics: the key to Healthcare for All
    Hasamnis AA, Patil SS, Shaik Imam, Narendiran K
    SRP. 2019; 10(1): s40-s42
    » Abstract » doi: 10.5530/srp.2019.1s.21

  • Deuterium Depleted Water as an Adjuvant in Treatment of Cancer
    Anton Syroeshkin, Olga Levitskaya, Elena Uspenskaya, Tatiana Pleteneva, Daria Romaykina, Daria Ermakova
    SRP. 2019; 10(1): 112-117
    » Abstract » doi: 10.5530/srp.2019.1.19

  • Most Downloaded
  • Dental Development between Assisted Reproductive Therapy (Art) and Natural Conceived Children: A Comparative Pilot Study
    Norzaiti Mohd Kenali, Naimah Hasanah Mohd Fathil, Norbasyirah Bohari, Ahmad Faisal Ismail, Roszaman Ramli
    SRP. 2020; 11(1): 01-06
    » Abstract » doi: 10.5530/srp.2020.1.01

  • Manilkara zapota (L.) Royen Fruit Peel: A Phytochemical and Pharmacological Review
    Karle Pravin P, Dhawale Shashikant C
    SRP. 2019; 10(1): 11-14
    » Abstract » doi: 0.5530/srp.2019.1.2

  • Pharmacognostic and Phytopharmacological Overview on Bombax ceiba
    Pankaj Haribhau Chaudhary, Mukund Ganeshrao Tawar
    SRP. 2019; 10(1): 20-25
    » Abstract » doi: 10.5530/srp.2019.1.4

  • A Review of Pharmacoeconomics: the key to Healthcare for All
    Hasamnis AA, Patil SS, Shaik Imam, Narendiran K
    SRP. 2019; 10(1): s40-s42
    » Abstract » doi: 10.5530/srp.2019.1s.21

  • A Prospective Review on Phyto-Pharmacological Aspects of Andrographis paniculata
    Govindraj Akilandeswari, Arumugam Vijaya Anand, Palanisamy Sampathkumar, Puthamohan Vinayaga Moorthi, Basavaraju Preethi
    SRP. 2019; 10(1): 15-19
    » Abstract » doi: 10.5530/srp.2019.1.3

  • Most Cited Articles