E-ISSN 0976-2779 | ISSN 0975-8453
 

Review Article 


A New Spectrophotometric Method for the determination of Cefepime in pharmaceutical preparation

Imad Tarek Hanoon.

Abstract
A simple spectrophotometric method was improved for the validation of cefepime (CE)in the pure and traditional drug forms. Themethodwas characterized inexpensive, rapid, sensitive, selective, and accurate. Itincludestwo reagentsforthe formation of azo dye.The methods involve CE diazonium salt in first reagent4-tetra-butylphenol, and in second reagent2,5-dimethylphenolinalkaline medium. The result obtained a stable red colored dye and gives absorption at 500nmand 515nm respectivelyagainst reagent blank. Law of Beer is obeyed in the concentration range of 1.0 – 50 µg. mL-1 with molar absorptivity of 6x103 and 4.5x103 L.mol-1.cm-1. Limit of detection was 0.316, 0.631 µg.mL-1, RSD% was 0.16, 0.23 and Sandell's sensitivity value 0.08, 0.01µg.cm-1respectively.

Key words: Spectrophotometry, cefepime, infections


 
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Pubmed Style

Imad Tarek Hanoon. A New Spectrophotometric Method for the determination of Cefepime in pharmaceutical preparation. SRP. 2020; 11(6): 330-336. doi:10.31838/srp.2020.6.52


Web Style

Imad Tarek Hanoon. A New Spectrophotometric Method for the determination of Cefepime in pharmaceutical preparation. http://www.sysrevpharm.org//?mno=115745 [Access: June 17, 2020]. doi:10.31838/srp.2020.6.52


AMA (American Medical Association) Style

Imad Tarek Hanoon. A New Spectrophotometric Method for the determination of Cefepime in pharmaceutical preparation. SRP. 2020; 11(6): 330-336. doi:10.31838/srp.2020.6.52



Vancouver/ICMJE Style

Imad Tarek Hanoon. A New Spectrophotometric Method for the determination of Cefepime in pharmaceutical preparation. SRP. (2020), [cited June 17, 2020]; 11(6): 330-336. doi:10.31838/srp.2020.6.52



Harvard Style

Imad Tarek Hanoon (2020) A New Spectrophotometric Method for the determination of Cefepime in pharmaceutical preparation. SRP, 11 (6), 330-336. doi:10.31838/srp.2020.6.52



Turabian Style

Imad Tarek Hanoon. 2020. A New Spectrophotometric Method for the determination of Cefepime in pharmaceutical preparation. Systematic Reviews in Pharmacy, 11 (6), 330-336. doi:10.31838/srp.2020.6.52



Chicago Style

Imad Tarek Hanoon. "A New Spectrophotometric Method for the determination of Cefepime in pharmaceutical preparation." Systematic Reviews in Pharmacy 11 (2020), 330-336. doi:10.31838/srp.2020.6.52



MLA (The Modern Language Association) Style

Imad Tarek Hanoon. "A New Spectrophotometric Method for the determination of Cefepime in pharmaceutical preparation." Systematic Reviews in Pharmacy 11.6 (2020), 330-336. Print. doi:10.31838/srp.2020.6.52



APA (American Psychological Association) Style

Imad Tarek Hanoon (2020) A New Spectrophotometric Method for the determination of Cefepime in pharmaceutical preparation. Systematic Reviews in Pharmacy, 11 (6), 330-336. doi:10.31838/srp.2020.6.52





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