E-ISSN 0976-2779 | ISSN 0975-8453
 

Review Article 


Assessing the Fat Mass and Obesity Associated Gene Polymorphisms (rs17817449 and rs1588413) in Obesity and Type 2 Diabetes Mellitus

Abdulhussein A. Algenabi, Majid K. Hussein, Najah R. Hadi, Fadhil A. Nasser, Ghizal Fatima, Hayder A. Al-Aubaidy.

Abstract
This study aims to evaluate the effects of FTO gene polymorphism (rs17817449andrs1588413) as predictor/ risk factors of type 2 diabetes mellitus in obese Iraqi population. Four hundred obese participants clinically diagnosed with type 2 diabetes were enrolled in this study. A similar matching group of obese non-diabetic control group was also included in this study. Multi-nominal logistic regression analysis applied to study genotype and allele frequencies for FTO gene polymorphism (rs17817449, rs1588413) in patients and control groups. The homozygous genotype significantly (OR= 4.61, CI 95% 2.61-8.12, P<0.001) increases the risk of T2DM by approximately two folds with regarding to those of the wild type after adjustment for other factors (age, sex and BMI).As for the FTO gene polymorphism (rs1588413): The homozygous genotype significantly (OR= 10.68, CI 95% 5.04-22.6, P<0.001) increased the risk of T2DM. The FTO gene polymorphisms rs17817449 and rs1588413are strong predictors for the development of type 2 diabetes mellitus in obese patients.

Key words: FTO gene polymorphisms; rs17817449; rs1588413; Type 2 diabetes; obesity


 
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Pubmed Style

Abdulhussein A. Algenabi, Majid K. Hussein, Najah R. Hadi, Fadhil A. Nasser, Ghizal Fatima, Hayder A. Al-Aubaidy. Assessing the Fat Mass and Obesity Associated Gene Polymorphisms (rs17817449 and rs1588413) in Obesity and Type 2 Diabetes Mellitus. SRP. 2020; 11(6): 656-660. doi:10.31838/srp.2020.6.97


Web Style

Abdulhussein A. Algenabi, Majid K. Hussein, Najah R. Hadi, Fadhil A. Nasser, Ghizal Fatima, Hayder A. Al-Aubaidy. Assessing the Fat Mass and Obesity Associated Gene Polymorphisms (rs17817449 and rs1588413) in Obesity and Type 2 Diabetes Mellitus. http://www.sysrevpharm.org//?mno=118324 [Access: June 24, 2020]. doi:10.31838/srp.2020.6.97


AMA (American Medical Association) Style

Abdulhussein A. Algenabi, Majid K. Hussein, Najah R. Hadi, Fadhil A. Nasser, Ghizal Fatima, Hayder A. Al-Aubaidy. Assessing the Fat Mass and Obesity Associated Gene Polymorphisms (rs17817449 and rs1588413) in Obesity and Type 2 Diabetes Mellitus. SRP. 2020; 11(6): 656-660. doi:10.31838/srp.2020.6.97



Vancouver/ICMJE Style

Abdulhussein A. Algenabi, Majid K. Hussein, Najah R. Hadi, Fadhil A. Nasser, Ghizal Fatima, Hayder A. Al-Aubaidy. Assessing the Fat Mass and Obesity Associated Gene Polymorphisms (rs17817449 and rs1588413) in Obesity and Type 2 Diabetes Mellitus. SRP. (2020), [cited June 24, 2020]; 11(6): 656-660. doi:10.31838/srp.2020.6.97



Harvard Style

Abdulhussein A. Algenabi, Majid K. Hussein, Najah R. Hadi, Fadhil A. Nasser, Ghizal Fatima, Hayder A. Al-Aubaidy (2020) Assessing the Fat Mass and Obesity Associated Gene Polymorphisms (rs17817449 and rs1588413) in Obesity and Type 2 Diabetes Mellitus. SRP, 11 (6), 656-660. doi:10.31838/srp.2020.6.97



Turabian Style

Abdulhussein A. Algenabi, Majid K. Hussein, Najah R. Hadi, Fadhil A. Nasser, Ghizal Fatima, Hayder A. Al-Aubaidy. 2020. Assessing the Fat Mass and Obesity Associated Gene Polymorphisms (rs17817449 and rs1588413) in Obesity and Type 2 Diabetes Mellitus. Systematic Reviews in Pharmacy, 11 (6), 656-660. doi:10.31838/srp.2020.6.97



Chicago Style

Abdulhussein A. Algenabi, Majid K. Hussein, Najah R. Hadi, Fadhil A. Nasser, Ghizal Fatima, Hayder A. Al-Aubaidy. "Assessing the Fat Mass and Obesity Associated Gene Polymorphisms (rs17817449 and rs1588413) in Obesity and Type 2 Diabetes Mellitus." Systematic Reviews in Pharmacy 11 (2020), 656-660. doi:10.31838/srp.2020.6.97



MLA (The Modern Language Association) Style

Abdulhussein A. Algenabi, Majid K. Hussein, Najah R. Hadi, Fadhil A. Nasser, Ghizal Fatima, Hayder A. Al-Aubaidy. "Assessing the Fat Mass and Obesity Associated Gene Polymorphisms (rs17817449 and rs1588413) in Obesity and Type 2 Diabetes Mellitus." Systematic Reviews in Pharmacy 11.6 (2020), 656-660. Print. doi:10.31838/srp.2020.6.97



APA (American Psychological Association) Style

Abdulhussein A. Algenabi, Majid K. Hussein, Najah R. Hadi, Fadhil A. Nasser, Ghizal Fatima, Hayder A. Al-Aubaidy (2020) Assessing the Fat Mass and Obesity Associated Gene Polymorphisms (rs17817449 and rs1588413) in Obesity and Type 2 Diabetes Mellitus. Systematic Reviews in Pharmacy, 11 (6), 656-660. doi:10.31838/srp.2020.6.97





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