E-ISSN 0976-2779 | ISSN 0975-8453
 

Review Article 


Effect of Application of BMP2/TGF β1 in Traumatic Pulp of Osteoporotic Rat

Abdulla MW Al-shamma, Athraa Y. Al-Hijazi, Dhuha M Hasan.

Abstract
Introduction: Dental pulp tissue contains many undifferentiated mesenchymal cells, which have the ability to differentiate into different specialized cells. Induced pluripotent stem cells have been developed by various growth factors. The present study was designed to evaluate the effect of application of a combination BMP2/TGF β1 as capped material for traumatic pulp in osteoporotic rat.
Materials and Methods: Twelfth female rats (6 normal rat and other 6 osteoporotic rat)., their maxillary anterior teeth subjected to mechanical traumatized pulptomy, the left tooth has speared without treatment, while the right tooth capped with application of 0.5 μl of BMP2 and 0.5μl of TGF β1 .Evaluation of histological changes includes scoring of pulp inflammation and scoring of morphology and thickness of dentin bridge were estimated for all study groups.
Results: Histological examination of tooth with pulptomy capped by BMP-2&TGF β1 for both normal and osteoporotic rat showed formation of reparative dentin bridge and minimal inflammatory response with a significant differences value in comparison to control.
Conclusion: The study concludes that application of a combination of BMP-2&TGFβ1 enhanced tooth repair in osteoporotic rat.

Key words: BMP-2, osteoporosis, pulptomy, reparative dentin, TGF β1, tooth repair


 
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How to Cite this Article
Pubmed Style

Abdulla MW Al-shamma, Athraa Y. Al-Hijazi, Dhuha M Hasan. Effect of Application of BMP2/TGF β1 in Traumatic Pulp of Osteoporotic Rat. SRP. 2020; 11(6): 756-760. doi:10.31838/srp.2020.6.111


Web Style

Abdulla MW Al-shamma, Athraa Y. Al-Hijazi, Dhuha M Hasan. Effect of Application of BMP2/TGF β1 in Traumatic Pulp of Osteoporotic Rat. http://www.sysrevpharm.org//?mno=118827 [Access: June 25, 2020]. doi:10.31838/srp.2020.6.111


AMA (American Medical Association) Style

Abdulla MW Al-shamma, Athraa Y. Al-Hijazi, Dhuha M Hasan. Effect of Application of BMP2/TGF β1 in Traumatic Pulp of Osteoporotic Rat. SRP. 2020; 11(6): 756-760. doi:10.31838/srp.2020.6.111



Vancouver/ICMJE Style

Abdulla MW Al-shamma, Athraa Y. Al-Hijazi, Dhuha M Hasan. Effect of Application of BMP2/TGF β1 in Traumatic Pulp of Osteoporotic Rat. SRP. (2020), [cited June 25, 2020]; 11(6): 756-760. doi:10.31838/srp.2020.6.111



Harvard Style

Abdulla MW Al-shamma, Athraa Y. Al-Hijazi, Dhuha M Hasan (2020) Effect of Application of BMP2/TGF β1 in Traumatic Pulp of Osteoporotic Rat. SRP, 11 (6), 756-760. doi:10.31838/srp.2020.6.111



Turabian Style

Abdulla MW Al-shamma, Athraa Y. Al-Hijazi, Dhuha M Hasan. 2020. Effect of Application of BMP2/TGF β1 in Traumatic Pulp of Osteoporotic Rat. Systematic Reviews in Pharmacy, 11 (6), 756-760. doi:10.31838/srp.2020.6.111



Chicago Style

Abdulla MW Al-shamma, Athraa Y. Al-Hijazi, Dhuha M Hasan. "Effect of Application of BMP2/TGF β1 in Traumatic Pulp of Osteoporotic Rat." Systematic Reviews in Pharmacy 11 (2020), 756-760. doi:10.31838/srp.2020.6.111



MLA (The Modern Language Association) Style

Abdulla MW Al-shamma, Athraa Y. Al-Hijazi, Dhuha M Hasan. "Effect of Application of BMP2/TGF β1 in Traumatic Pulp of Osteoporotic Rat." Systematic Reviews in Pharmacy 11.6 (2020), 756-760. Print. doi:10.31838/srp.2020.6.111



APA (American Psychological Association) Style

Abdulla MW Al-shamma, Athraa Y. Al-Hijazi, Dhuha M Hasan (2020) Effect of Application of BMP2/TGF β1 in Traumatic Pulp of Osteoporotic Rat. Systematic Reviews in Pharmacy, 11 (6), 756-760. doi:10.31838/srp.2020.6.111





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