E-ISSN 0976-2779 | ISSN 0975-8453
 

Review Article 


The Relationship of Vitamin D Serum Levels with The Lowering of The Left Ventricular Systolic Function in Women with Locally Advanced Breast Cancer Undergoing Doxorubicin Chemotherapy

Rheno Arditya, Hantoro Ishardyanto, Achmad Lefi, Edwin Danardono4.

Abstract
Chemotherapy with doxorubicin in breast cancer patients can cause cardiotoxicity and increase mortality by up to 50%. Vitamin D can cause indirect effects on decreasing heart function. This study examined the relationship of serum blood vitamin D levels with decreased left ventricular systolic function in women with locally advanced breast cancer (LBAC) undergoing doxorubicin chemotherapy. This was an analytical observational study with cross-sectional design. Data collection for vitamin D and echocardiography was performed on patients undergoing chemotherapy for one year. The data were then tested using the contingency coefficient test and regression test. This study found vitamin D deficiency in 17 persons (56.7%). On echocardiography examination, the mean left ventricular ejection fraction (LVEF) was obtained before administering neoadjuvant chemotherapy by 65.0±3, and the average LVEF after administration of neoadjuvant chemotherapy was 61.80±6.283. A total of 18 patients (60%) experienced decreased left ventricular systolic function. There was a significant relationship between vitamin D levels and decreased left ventricular systolic function (p = 0.007). There was a statistically significant relationship between vitamin D levels and decreased systolic function in women with LBAC undergoing neoadjuvant chemotherapy. The higher serum vitamin D level, the lower the decrease in left ventricular systolic function after undergoing Doxorubicin chemotherapy.

Key words: Locally advanced breast cancer, vitamin D, left ventricle ejection fraction (LVEF), doxorubicin


 
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How to Cite this Article
Pubmed Style

Arditya R, Ishardyanto H, Lefi A, Danardono E. The Relationship of Vitamin D Serum Levels with The Lowering of The Left Ventricular Systolic Function in Women with Locally Advanced Breast Cancer Undergoing Doxorubicin Chemotherapy. SRP. 2020; 11(6): 983-986. doi:10.31838/srp.2020.6.139


Web Style

Arditya R, Ishardyanto H, Lefi A, Danardono E. The Relationship of Vitamin D Serum Levels with The Lowering of The Left Ventricular Systolic Function in Women with Locally Advanced Breast Cancer Undergoing Doxorubicin Chemotherapy. http://www.sysrevpharm.org//?mno=30538 [Access: July 07, 2020]. doi:10.31838/srp.2020.6.139


AMA (American Medical Association) Style

Arditya R, Ishardyanto H, Lefi A, Danardono E. The Relationship of Vitamin D Serum Levels with The Lowering of The Left Ventricular Systolic Function in Women with Locally Advanced Breast Cancer Undergoing Doxorubicin Chemotherapy. SRP. 2020; 11(6): 983-986. doi:10.31838/srp.2020.6.139



Vancouver/ICMJE Style

Arditya R, Ishardyanto H, Lefi A, Danardono E. The Relationship of Vitamin D Serum Levels with The Lowering of The Left Ventricular Systolic Function in Women with Locally Advanced Breast Cancer Undergoing Doxorubicin Chemotherapy. SRP. (2020), [cited July 07, 2020]; 11(6): 983-986. doi:10.31838/srp.2020.6.139



Harvard Style

Arditya, R., Ishardyanto, . H., Lefi, . A. & Danardono, . E. (2020) The Relationship of Vitamin D Serum Levels with The Lowering of The Left Ventricular Systolic Function in Women with Locally Advanced Breast Cancer Undergoing Doxorubicin Chemotherapy. SRP, 11 (6), 983-986. doi:10.31838/srp.2020.6.139



Turabian Style

Arditya, Rheno, Hantoro Ishardyanto, Achmad Lefi, and Edwin Danardono. 2020. The Relationship of Vitamin D Serum Levels with The Lowering of The Left Ventricular Systolic Function in Women with Locally Advanced Breast Cancer Undergoing Doxorubicin Chemotherapy. Systematic Reviews in Pharmacy, 11 (6), 983-986. doi:10.31838/srp.2020.6.139



Chicago Style

Arditya, Rheno, Hantoro Ishardyanto, Achmad Lefi, and Edwin Danardono. "The Relationship of Vitamin D Serum Levels with The Lowering of The Left Ventricular Systolic Function in Women with Locally Advanced Breast Cancer Undergoing Doxorubicin Chemotherapy." Systematic Reviews in Pharmacy 11 (2020), 983-986. doi:10.31838/srp.2020.6.139



MLA (The Modern Language Association) Style

Arditya, Rheno, Hantoro Ishardyanto, Achmad Lefi, and Edwin Danardono. "The Relationship of Vitamin D Serum Levels with The Lowering of The Left Ventricular Systolic Function in Women with Locally Advanced Breast Cancer Undergoing Doxorubicin Chemotherapy." Systematic Reviews in Pharmacy 11.6 (2020), 983-986. Print. doi:10.31838/srp.2020.6.139



APA (American Psychological Association) Style

Arditya, R., Ishardyanto, . H., Lefi, . A. & Danardono, . E. (2020) The Relationship of Vitamin D Serum Levels with The Lowering of The Left Ventricular Systolic Function in Women with Locally Advanced Breast Cancer Undergoing Doxorubicin Chemotherapy. Systematic Reviews in Pharmacy, 11 (6), 983-986. doi:10.31838/srp.2020.6.139





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