E-ISSN 0976-2779 | ISSN 0975-8453
 

Review Article 


Combined Fractional Erbuim-YAG Laser With Botulinum Toxin-A Versus Botulinum Toxin-A Alone For The Treatment Of Hypertrophic Scars And Keloids

Seif -Allah Mohamed Elfiky, Hisham Shokeir, Mahmoud S Elbasiouny, Nevien Samy.

Abstract
Background:
The treatment of hypertrophic scars (HTS) and keloids remains a challenge. Not all treatment modalities have been adequately tested.
Objectives:
We aimed to compare the efficacy between combined fractional Er:YAG with intra-lesional botulinum toxin (Botox) and intra-lesional Botox as a monotherapy for the treatment of HTS and keloids.
Patients and methods:
Thirty patients with HTS and keloids were treated by intra-lesional injection of Botulinum Toxin Type –A (Botox) as a monotherapy and Botox combined with ablative fractional Er:YAG laser. Each lesion was divided into two parts. The allocation of treatment method was randomly selected. One part was treated with Botox intra-lesionally 5 IU/cm2. The other part was subjected to combined intra-lesional Botox and ablative fractional Er:YAG laser (2,940 nm) sessions (4 sessions every 4 weeks). Evaluation of the treatment outcomes was done by the Vancouver Scar Scale (VSS), clinical imaging, and immuno-histochemical studies.
Results:
There was a significant decline in VSS after treatment with the combined regimen compared to the sites treated with botox injection only (P<0.001). Additionally, there was a highly significant difference between the combined treated sides and the Botox monotherapy sides in both the epidermal thickness (P=0.001) and area% hypodermis (P=0.001).
Conclusion:
Treatment of HTS and keloids with the combined approach of Er:YAG and Botox is more effective than Botox alone.

Key words: Combined Fractional Erbuim-YAG Laser With Botulinum, Toxin-A Versus Botulinum Toxin-A Alone, Treatment Of Hypertrophic Scars And Keloids


 
ARTICLE TOOLS
Abstract
PDF Fulltext
How to cite this articleHow to cite this article
Citation Tools
Related Records
 Articles by Seif -Allah Mohamed Elfiky
Articles by Hisham Shokeir
Articles by Mahmoud S Elbasiouny
Articles by Nevien Samy
on Google
on Google Scholar


How to Cite this Article
Pubmed Style

Seif -Allah Mohamed Elfiky, Hisham Shokeir, Mahmoud S Elbasiouny, Nevien Samy. Combined Fractional Erbuim-YAG Laser With Botulinum Toxin-A Versus Botulinum Toxin-A Alone For The Treatment Of Hypertrophic Scars And Keloids. SRP. 2021; 12(3): 115-120. doi:10.31838/srp.2021.3.20


Web Style

Seif -Allah Mohamed Elfiky, Hisham Shokeir, Mahmoud S Elbasiouny, Nevien Samy. Combined Fractional Erbuim-YAG Laser With Botulinum Toxin-A Versus Botulinum Toxin-A Alone For The Treatment Of Hypertrophic Scars And Keloids. http://www.sysrevpharm.org/?mno=51606 [Access: March 05, 2021]. doi:10.31838/srp.2021.3.20


AMA (American Medical Association) Style

Seif -Allah Mohamed Elfiky, Hisham Shokeir, Mahmoud S Elbasiouny, Nevien Samy. Combined Fractional Erbuim-YAG Laser With Botulinum Toxin-A Versus Botulinum Toxin-A Alone For The Treatment Of Hypertrophic Scars And Keloids. SRP. 2021; 12(3): 115-120. doi:10.31838/srp.2021.3.20



Vancouver/ICMJE Style

Seif -Allah Mohamed Elfiky, Hisham Shokeir, Mahmoud S Elbasiouny, Nevien Samy. Combined Fractional Erbuim-YAG Laser With Botulinum Toxin-A Versus Botulinum Toxin-A Alone For The Treatment Of Hypertrophic Scars And Keloids. SRP. (2021), [cited March 05, 2021]; 12(3): 115-120. doi:10.31838/srp.2021.3.20



Harvard Style

Seif -Allah Mohamed Elfiky, Hisham Shokeir, Mahmoud S Elbasiouny, Nevien Samy (2021) Combined Fractional Erbuim-YAG Laser With Botulinum Toxin-A Versus Botulinum Toxin-A Alone For The Treatment Of Hypertrophic Scars And Keloids. SRP, 12 (3), 115-120. doi:10.31838/srp.2021.3.20



Turabian Style

Seif -Allah Mohamed Elfiky, Hisham Shokeir, Mahmoud S Elbasiouny, Nevien Samy. 2021. Combined Fractional Erbuim-YAG Laser With Botulinum Toxin-A Versus Botulinum Toxin-A Alone For The Treatment Of Hypertrophic Scars And Keloids. Systematic Reviews in Pharmacy, 12 (3), 115-120. doi:10.31838/srp.2021.3.20



Chicago Style

Seif -Allah Mohamed Elfiky, Hisham Shokeir, Mahmoud S Elbasiouny, Nevien Samy. "Combined Fractional Erbuim-YAG Laser With Botulinum Toxin-A Versus Botulinum Toxin-A Alone For The Treatment Of Hypertrophic Scars And Keloids." Systematic Reviews in Pharmacy 12 (2021), 115-120. doi:10.31838/srp.2021.3.20



MLA (The Modern Language Association) Style

Seif -Allah Mohamed Elfiky, Hisham Shokeir, Mahmoud S Elbasiouny, Nevien Samy. "Combined Fractional Erbuim-YAG Laser With Botulinum Toxin-A Versus Botulinum Toxin-A Alone For The Treatment Of Hypertrophic Scars And Keloids." Systematic Reviews in Pharmacy 12.3 (2021), 115-120. Print. doi:10.31838/srp.2021.3.20



APA (American Psychological Association) Style

Seif -Allah Mohamed Elfiky, Hisham Shokeir, Mahmoud S Elbasiouny, Nevien Samy (2021) Combined Fractional Erbuim-YAG Laser With Botulinum Toxin-A Versus Botulinum Toxin-A Alone For The Treatment Of Hypertrophic Scars And Keloids. Systematic Reviews in Pharmacy, 12 (3), 115-120. doi:10.31838/srp.2021.3.20





Most Viewed Articles
  • Dental Development between Assisted Reproductive Therapy (Art) and Natural Conceived Children: A Comparative Pilot Study
    Norzaiti Mohd Kenali, Naimah Hasanah Mohd Fathil, Norbasyirah Bohari, Ahmad Faisal Ismail, Roszaman Ramli
    SRP. 2020; 11(1): 01-06
    » Abstract » doi: 10.5530/srp.2020.1.01

  • Psychometric properties of the World Health Organization Quality of life instrument, short form: Validity in the Vietnamese healthcare context
    Trung Quang Vo*, Bao Tran Thuy Tran, Ngan Thuy Nguyen, Tram ThiHuyen Nguyen, Thuy Phan Chung Tran
    SRP. 2020; 11(1): 14-22
    » Abstract » doi: 10.5530/srp.2020.1.03

  • A Prospective Review on Phyto-Pharmacological Aspects of Andrographis paniculata
    Govindraj Akilandeswari, Arumugam Vijaya Anand, Palanisamy Sampathkumar, Puthamohan Vinayaga Moorthi, Basavaraju Preethi
    SRP. 2019; 10(1): 15-19
    » Abstract » doi: 10.5530/srp.2019.1.3

  • A Review of Pharmacoeconomics: the key to “Healthcare for All”
    Hasamnis AA, Patil SS, Shaik Imam, Narendiran K
    SRP. 2019; 10(1): s40-s42
    » Abstract » doi: 10.5530/srp.2019.1s.21

  • Deuterium Depleted Water as an Adjuvant in Treatment of Cancer
    Anton Syroeshkin, Olga Levitskaya, Elena Uspenskaya, Tatiana Pleteneva, Daria Romaykina, Daria Ermakova
    SRP. 2019; 10(1): 112-117
    » Abstract » doi: 10.5530/srp.2019.1.19

  • Most Downloaded
  • Dental Development between Assisted Reproductive Therapy (Art) and Natural Conceived Children: A Comparative Pilot Study
    Norzaiti Mohd Kenali, Naimah Hasanah Mohd Fathil, Norbasyirah Bohari, Ahmad Faisal Ismail, Roszaman Ramli
    SRP. 2020; 11(1): 01-06
    » Abstract » doi: 10.5530/srp.2020.1.01

  • Manilkara zapota (L.) Royen Fruit Peel: A Phytochemical and Pharmacological Review
    Karle Pravin P, Dhawale Shashikant C
    SRP. 2019; 10(1): 11-14
    » Abstract » doi: 0.5530/srp.2019.1.2

  • Pharmacognostic and Phytopharmacological Overview on Bombax ceiba
    Pankaj Haribhau Chaudhary, Mukund Ganeshrao Tawar
    SRP. 2019; 10(1): 20-25
    » Abstract » doi: 10.5530/srp.2019.1.4

  • A Review of Pharmacoeconomics: the key to “Healthcare for All”
    Hasamnis AA, Patil SS, Shaik Imam, Narendiran K
    SRP. 2019; 10(1): s40-s42
    » Abstract » doi: 10.5530/srp.2019.1s.21

  • A Prospective Review on Phyto-Pharmacological Aspects of Andrographis paniculata
    Govindraj Akilandeswari, Arumugam Vijaya Anand, Palanisamy Sampathkumar, Puthamohan Vinayaga Moorthi, Basavaraju Preethi
    SRP. 2019; 10(1): 15-19
    » Abstract » doi: 10.5530/srp.2019.1.3

  • Most Cited Articles