Abstract
Psoriasis has been identified as a chronic disease of the skin in which inflammations are produced, which is impacting 2-3% of population in almost every country around the globe. The study was a systematic review with an objective to figure out the different methods used in the biological therapy and clinical trials of those in the treatment of psoriasis, to study the retrospective analysis of biological therapy for psoriasis in different clinical trials and to compare the results of retrospective analysis of biological therapy for psoriasis with the existing ones. The researcher conducted analysis of 65 studies, which were extracted from a pool of 200 studies taken from different medical databases. The results showed that novel methods of therapies are bearing efficient results and are more effective than previous ones. The results also showed the most to least effective therapies for psoriasis, the most efficient marked was the usage of anti-IL-7 inhibitors (Adalimumab) with 80% of success rate and the least one was the usage of interleukin (IL)-23/Th17, yet with a success rate of 66%. For the purpose of disease prevention, awareness of causes is necessary and for the treatment, awareness of the most reliable and effective method of therapy is necessary. In the current study, both of these have been provided by the researcher, however, the study has its limitations based on the number of studies selected for analysis and the way they were selected.

Key words: Biological, Therapies, Psoriasis, Disease, Skin, Systematic Review