E-ISSN 0976-2779 | ISSN 0975-8453
 

Review Article 


Synthesis, Characterization, and Antibacterial Study of New Ligands Derived from Nalidixic acid

Dunya AL-Duhaidahawi, Hanaa Jaffer AlKabee, Meison Abdulbary, Hayder H. AL-Ghuraibawi.

Abstract
A novel compounds of nalidixic acid derivatives were synthesized by a coupling reaction with 2-aminothiazole-5-carbaldehyde using DIC as coupling reagent and HOBt as racemization suppressant then the product of reaction treated with different amine tail like 2-(methylthio) Ethan amine that result in compound 1 while refluxing with 2-(4-methyl piperazine-1-yl) Ethan amine and 2-(pyrrolidine-1-yl) Ethan amine results in compound 2 and 4 respectively. All the synthesized compounds were adequately identified by spectral studies utilizing IR and elemental analysis and assessed for their in vitro antibacterial activity in contradiction of different type of bacteria. All the tested molecules against bacterial strains compared with the nalidixic acid as a reference drug in this study. Results indicated that compounds 1, 2 & 4 have good antibacterial activities compared to standard drug especially as they were found to have promising activity against Bacillus and to be as effective as nalidixic acid toward psudomonus and E coli.

Key words: Nalidixic acid; coupling reaction; Schiff base; disc diffusion method; 2-aminothiazole-5-carbaldehyde;


 
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Pubmed Style

Dunya AL-Duhaidahawi, Hanaa Jaffer AlKabee, Meison Abdulbary, Hayder H. AL-Ghuraibawi. Synthesis, Characterization, and Antibacterial Study of New Ligands Derived from Nalidixic acid. SRP. 2020; 11(2): 77-81. doi:10.5530/srp.2020.2.13


Web Style

Dunya AL-Duhaidahawi, Hanaa Jaffer AlKabee, Meison Abdulbary, Hayder H. AL-Ghuraibawi. Synthesis, Characterization, and Antibacterial Study of New Ligands Derived from Nalidixic acid. http://www.sysrevpharm.org//?mno=86866 [Access: February 20, 2020]. doi:10.5530/srp.2020.2.13


AMA (American Medical Association) Style

Dunya AL-Duhaidahawi, Hanaa Jaffer AlKabee, Meison Abdulbary, Hayder H. AL-Ghuraibawi. Synthesis, Characterization, and Antibacterial Study of New Ligands Derived from Nalidixic acid. SRP. 2020; 11(2): 77-81. doi:10.5530/srp.2020.2.13



Vancouver/ICMJE Style

Dunya AL-Duhaidahawi, Hanaa Jaffer AlKabee, Meison Abdulbary, Hayder H. AL-Ghuraibawi. Synthesis, Characterization, and Antibacterial Study of New Ligands Derived from Nalidixic acid. SRP. (2020), [cited February 20, 2020]; 11(2): 77-81. doi:10.5530/srp.2020.2.13



Harvard Style

Dunya AL-Duhaidahawi, Hanaa Jaffer AlKabee, Meison Abdulbary, Hayder H. AL-Ghuraibawi (2020) Synthesis, Characterization, and Antibacterial Study of New Ligands Derived from Nalidixic acid. SRP, 11 (2), 77-81. doi:10.5530/srp.2020.2.13



Turabian Style

Dunya AL-Duhaidahawi, Hanaa Jaffer AlKabee, Meison Abdulbary, Hayder H. AL-Ghuraibawi. 2020. Synthesis, Characterization, and Antibacterial Study of New Ligands Derived from Nalidixic acid. Systematic Reviews in Pharmacy, 11 (2), 77-81. doi:10.5530/srp.2020.2.13



Chicago Style

Dunya AL-Duhaidahawi, Hanaa Jaffer AlKabee, Meison Abdulbary, Hayder H. AL-Ghuraibawi. "Synthesis, Characterization, and Antibacterial Study of New Ligands Derived from Nalidixic acid." Systematic Reviews in Pharmacy 11 (2020), 77-81. doi:10.5530/srp.2020.2.13



MLA (The Modern Language Association) Style

Dunya AL-Duhaidahawi, Hanaa Jaffer AlKabee, Meison Abdulbary, Hayder H. AL-Ghuraibawi. "Synthesis, Characterization, and Antibacterial Study of New Ligands Derived from Nalidixic acid." Systematic Reviews in Pharmacy 11.2 (2020), 77-81. Print. doi:10.5530/srp.2020.2.13



APA (American Psychological Association) Style

Dunya AL-Duhaidahawi, Hanaa Jaffer AlKabee, Meison Abdulbary, Hayder H. AL-Ghuraibawi (2020) Synthesis, Characterization, and Antibacterial Study of New Ligands Derived from Nalidixic acid. Systematic Reviews in Pharmacy, 11 (2), 77-81. doi:10.5530/srp.2020.2.13





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