E-ISSN 0976-2779 | ISSN 0975-8453
 

Review Article 


The State of Systemic and Local Immunity with Non Specific Vulvovaginitis in Adolescents

Smailova Lazat, Iskakov Serik, Tuletova Ainur, Shegenov Galym, Aketaeva Asem.

Abstract
The study showed that there is a secondary immune deficiency in the subacute course, and in acute immune deficiency it was not detected. In acute course compared with subacute one, there is an increased production of IFN-γ, which indicates the direct dependence of the pro-inflammatory cytokines activity level on the clinical course of the inflammatory process.
A study of vaginal secretion phagocytosis revealed that in acute cases, the phagocytic function of the local secretion is satisfactory, while in the subacute case, satisfactory absorption function decreases the bactericidal activity of the vaginal secretion, which indicates the need for correction of the phagocytic link.
The use of Roncoleukin parenterally in acute course does not affect normal immune status indicators, i.e. has a modulating effect depending on the initial immune status. In subacute case, local application leads to an increase in the absorption and oxygen-dependent bactericidal ability of the vaginal secretion, which contributes to the rapid regression of the clinical manifestations of vulvovaginitis, parenterally leading to normalization of the main indicators of the subpopulation composition of lymphocytes.

Key words: Teenager, vulvovaginitis, immunity, cytokines, phagocytosis, roncoleukin


 
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How to Cite this Article
Pubmed Style

Smailova Lazat, Iskakov Serik, Tuletova Ainur, Shegenov Galym, Aketaeva Asem. The State of Systemic and Local Immunity with Non Specific Vulvovaginitis in Adolescents. SRP. 2020; 11(3): 515-520. doi:10.5530/srp.2020.3.66


Web Style

Smailova Lazat, Iskakov Serik, Tuletova Ainur, Shegenov Galym, Aketaeva Asem. The State of Systemic and Local Immunity with Non Specific Vulvovaginitis in Adolescents. http://www.sysrevpharm.org//?mno=95597 [Access: June 01, 2020]. doi:10.5530/srp.2020.3.66


AMA (American Medical Association) Style

Smailova Lazat, Iskakov Serik, Tuletova Ainur, Shegenov Galym, Aketaeva Asem. The State of Systemic and Local Immunity with Non Specific Vulvovaginitis in Adolescents. SRP. 2020; 11(3): 515-520. doi:10.5530/srp.2020.3.66



Vancouver/ICMJE Style

Smailova Lazat, Iskakov Serik, Tuletova Ainur, Shegenov Galym, Aketaeva Asem. The State of Systemic and Local Immunity with Non Specific Vulvovaginitis in Adolescents. SRP. (2020), [cited June 01, 2020]; 11(3): 515-520. doi:10.5530/srp.2020.3.66



Harvard Style

Smailova Lazat, Iskakov Serik, Tuletova Ainur, Shegenov Galym, Aketaeva Asem (2020) The State of Systemic and Local Immunity with Non Specific Vulvovaginitis in Adolescents. SRP, 11 (3), 515-520. doi:10.5530/srp.2020.3.66



Turabian Style

Smailova Lazat, Iskakov Serik, Tuletova Ainur, Shegenov Galym, Aketaeva Asem. 2020. The State of Systemic and Local Immunity with Non Specific Vulvovaginitis in Adolescents. Systematic Reviews in Pharmacy, 11 (3), 515-520. doi:10.5530/srp.2020.3.66



Chicago Style

Smailova Lazat, Iskakov Serik, Tuletova Ainur, Shegenov Galym, Aketaeva Asem. "The State of Systemic and Local Immunity with Non Specific Vulvovaginitis in Adolescents." Systematic Reviews in Pharmacy 11 (2020), 515-520. doi:10.5530/srp.2020.3.66



MLA (The Modern Language Association) Style

Smailova Lazat, Iskakov Serik, Tuletova Ainur, Shegenov Galym, Aketaeva Asem. "The State of Systemic and Local Immunity with Non Specific Vulvovaginitis in Adolescents." Systematic Reviews in Pharmacy 11.3 (2020), 515-520. Print. doi:10.5530/srp.2020.3.66



APA (American Psychological Association) Style

Smailova Lazat, Iskakov Serik, Tuletova Ainur, Shegenov Galym, Aketaeva Asem (2020) The State of Systemic and Local Immunity with Non Specific Vulvovaginitis in Adolescents. Systematic Reviews in Pharmacy, 11 (3), 515-520. doi:10.5530/srp.2020.3.66