E-ISSN 0976-2779 | ISSN 0975-8453
 

Review Article 


Simvastatin Effect on High-Sensitivity C-Reactive Protein in Type 2 Diabetes Mellitus

Jongky Hendro Prajitno, Soebagijo Adi Soelistijo, Agung Pranoto.

Abstract
Cardiovascular disease (CVD) as a complication of type 2 diabetes mellitus (T2DM) is associated with chronic low-grade inflammation. Statin has an anti-inflammatory effect that is marked by decreasing inflammatory marker, such as high-sensitivity C-reactive protein (hsCRP). This study aims to evaluate the administration of simvastatin in influencing hsCRP level in patients with T2DM. A randomized control study involving subjects with T2DM which divided into two groups was conducted. Pre- and post-treatment measurements of lipid profile, HbA1c, hsCRP were performed in both groups. Triglyceride and HbA1c levels were significantly different between two groups (p=0.001, p=0.016, respectively). Only HbA1c was significantly associated with pre-treatment hsCRP level (p = 0,006). After three months, statin group showed significantly lower hsCRP level than that before treatment (p=0.002). Moreover, pre- and post-treatment differences of hsCRP level in both groups were also significant (0.410.26 vs -0.130.32, respectively, p=0.003).Simvastatin could reduce inflammation in T2DM patients that was marked by decreasing level of hsCRP.

Key words: simvastatin, high-sensitivity C-reactive protein, type 2 diabetes mellitus, inflammation


 
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How to Cite this Article
Pubmed Style

Jongky Hendro Prajitno, Soebagijo Adi Soelistijo, Agung Pranoto. Simvastatin Effect on High-Sensitivity C-Reactive Protein in Type 2 Diabetes Mellitus. SRP. 2020; 11(3): 618-623. doi:10.31838/srp.2020.3.82


Web Style

Jongky Hendro Prajitno, Soebagijo Adi Soelistijo, Agung Pranoto. Simvastatin Effect on High-Sensitivity C-Reactive Protein in Type 2 Diabetes Mellitus. http://www.sysrevpharm.org//?mno=96039 [Access: June 01, 2020]. doi:10.31838/srp.2020.3.82


AMA (American Medical Association) Style

Jongky Hendro Prajitno, Soebagijo Adi Soelistijo, Agung Pranoto. Simvastatin Effect on High-Sensitivity C-Reactive Protein in Type 2 Diabetes Mellitus. SRP. 2020; 11(3): 618-623. doi:10.31838/srp.2020.3.82



Vancouver/ICMJE Style

Jongky Hendro Prajitno, Soebagijo Adi Soelistijo, Agung Pranoto. Simvastatin Effect on High-Sensitivity C-Reactive Protein in Type 2 Diabetes Mellitus. SRP. (2020), [cited June 01, 2020]; 11(3): 618-623. doi:10.31838/srp.2020.3.82



Harvard Style

Jongky Hendro Prajitno, Soebagijo Adi Soelistijo, Agung Pranoto (2020) Simvastatin Effect on High-Sensitivity C-Reactive Protein in Type 2 Diabetes Mellitus. SRP, 11 (3), 618-623. doi:10.31838/srp.2020.3.82



Turabian Style

Jongky Hendro Prajitno, Soebagijo Adi Soelistijo, Agung Pranoto. 2020. Simvastatin Effect on High-Sensitivity C-Reactive Protein in Type 2 Diabetes Mellitus. Systematic Reviews in Pharmacy, 11 (3), 618-623. doi:10.31838/srp.2020.3.82



Chicago Style

Jongky Hendro Prajitno, Soebagijo Adi Soelistijo, Agung Pranoto. "Simvastatin Effect on High-Sensitivity C-Reactive Protein in Type 2 Diabetes Mellitus." Systematic Reviews in Pharmacy 11 (2020), 618-623. doi:10.31838/srp.2020.3.82



MLA (The Modern Language Association) Style

Jongky Hendro Prajitno, Soebagijo Adi Soelistijo, Agung Pranoto. "Simvastatin Effect on High-Sensitivity C-Reactive Protein in Type 2 Diabetes Mellitus." Systematic Reviews in Pharmacy 11.3 (2020), 618-623. Print. doi:10.31838/srp.2020.3.82



APA (American Psychological Association) Style

Jongky Hendro Prajitno, Soebagijo Adi Soelistijo, Agung Pranoto (2020) Simvastatin Effect on High-Sensitivity C-Reactive Protein in Type 2 Diabetes Mellitus. Systematic Reviews in Pharmacy, 11 (3), 618-623. doi:10.31838/srp.2020.3.82