E-ISSN 0976-2779 | ISSN 0975-8453
 

Review Article 


The Correlation of Imatinib Therapy Duration and Esti-mated Glomerular Filtration Rate in Chronic Myeloid Leukemia Patients

S. Ugroseno Yudho Bintoro, Agus Prabowo, Made Putra Sedana, Ami Ashariati, Artaria Tjempakasa-ri.

Abstract
Chronic myeloid leukemia (CML) is a chronic myeloproliferative dis-ease. Treatment of CML with TKI may cause changes in glomerular filtration rate (GFR) over time. The objective of the study was to analyze the correlation of imatinib therapy duration and eGFR in CML patients in outpatient clinic of Dr. Soetomo Hospital, Surabaya. This was an observational analytic cross-sectional study. The duration of imatinib therapy was more than three months and estimated glomeru-lar filtration rate (eGFR) as measured using the CKD-EPI creatinine equation. Among the 64 subjects studied, most of them were male as many as 76.6%. The mean age was 41.36 years. The mean serum creatinine level was 0.959 mg/dL. The mean eGFR was 93.184 mL/min/1.73m2. The mean duration of therapy for imatinib was 30.66 months. There was a significant inverse relationship between the duration of imatinib therapy and eGFR (r = -0.470; p <0.001). There was a significant negative correla-tion between the duration of imatinib therapy with eGFR in CML pa-tients.

Key words: Duration of imatinib therapy, estimated glomerular filtration rate (eGFR), CML patients


 
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How to Cite this Article
Pubmed Style

S. Ugroseno Yudho Bintoro, Agus Prabowo, Made Putra Sedana, Ami Ashariati, Artaria Tjempakasa-ri. The Correlation of Imatinib Therapy Duration and Esti-mated Glomerular Filtration Rate in Chronic Myeloid Leukemia Patients. SRP. 2020; 11(3): 657-660. doi:10.31838/srp.2020.3.88


Web Style

S. Ugroseno Yudho Bintoro, Agus Prabowo, Made Putra Sedana, Ami Ashariati, Artaria Tjempakasa-ri. The Correlation of Imatinib Therapy Duration and Esti-mated Glomerular Filtration Rate in Chronic Myeloid Leukemia Patients. http://www.sysrevpharm.org//?mno=96312 [Access: June 01, 2020]. doi:10.31838/srp.2020.3.88


AMA (American Medical Association) Style

S. Ugroseno Yudho Bintoro, Agus Prabowo, Made Putra Sedana, Ami Ashariati, Artaria Tjempakasa-ri. The Correlation of Imatinib Therapy Duration and Esti-mated Glomerular Filtration Rate in Chronic Myeloid Leukemia Patients. SRP. 2020; 11(3): 657-660. doi:10.31838/srp.2020.3.88



Vancouver/ICMJE Style

S. Ugroseno Yudho Bintoro, Agus Prabowo, Made Putra Sedana, Ami Ashariati, Artaria Tjempakasa-ri. The Correlation of Imatinib Therapy Duration and Esti-mated Glomerular Filtration Rate in Chronic Myeloid Leukemia Patients. SRP. (2020), [cited June 01, 2020]; 11(3): 657-660. doi:10.31838/srp.2020.3.88



Harvard Style

S. Ugroseno Yudho Bintoro, Agus Prabowo, Made Putra Sedana, Ami Ashariati, Artaria Tjempakasa-ri (2020) The Correlation of Imatinib Therapy Duration and Esti-mated Glomerular Filtration Rate in Chronic Myeloid Leukemia Patients. SRP, 11 (3), 657-660. doi:10.31838/srp.2020.3.88



Turabian Style

S. Ugroseno Yudho Bintoro, Agus Prabowo, Made Putra Sedana, Ami Ashariati, Artaria Tjempakasa-ri. 2020. The Correlation of Imatinib Therapy Duration and Esti-mated Glomerular Filtration Rate in Chronic Myeloid Leukemia Patients. Systematic Reviews in Pharmacy, 11 (3), 657-660. doi:10.31838/srp.2020.3.88



Chicago Style

S. Ugroseno Yudho Bintoro, Agus Prabowo, Made Putra Sedana, Ami Ashariati, Artaria Tjempakasa-ri. "The Correlation of Imatinib Therapy Duration and Esti-mated Glomerular Filtration Rate in Chronic Myeloid Leukemia Patients." Systematic Reviews in Pharmacy 11 (2020), 657-660. doi:10.31838/srp.2020.3.88



MLA (The Modern Language Association) Style

S. Ugroseno Yudho Bintoro, Agus Prabowo, Made Putra Sedana, Ami Ashariati, Artaria Tjempakasa-ri. "The Correlation of Imatinib Therapy Duration and Esti-mated Glomerular Filtration Rate in Chronic Myeloid Leukemia Patients." Systematic Reviews in Pharmacy 11.3 (2020), 657-660. Print. doi:10.31838/srp.2020.3.88



APA (American Psychological Association) Style

S. Ugroseno Yudho Bintoro, Agus Prabowo, Made Putra Sedana, Ami Ashariati, Artaria Tjempakasa-ri (2020) The Correlation of Imatinib Therapy Duration and Esti-mated Glomerular Filtration Rate in Chronic Myeloid Leukemia Patients. Systematic Reviews in Pharmacy, 11 (3), 657-660. doi:10.31838/srp.2020.3.88