E-ISSN 0976-2779 | ISSN 0975-8453
 

Review Article 


Estimation of Truffles Extracts and Study the Biological Efficacy of Ethyl 6-methyl-2-oxo-4-(2-thienyl)-1,2,3,4- tetrahydropyrimidine-5-carboxylate (EMOTTC) as One of the Extracts against Ophthalmic Bacteria

Rana D. S. ALkamil, Dawood CH. Al-Bahadily, Rasool Chaloob, Falah Hassan Shari, H. N. K. AL-Salman*.

Abstract
Context: The study indicated to the biological effectiveness of the
compound is Ethyl 6-methyl-2-oxo-4- (2-thienyl) -1,2,3,4-
tetrahydropyrimidine-5-carboxylate (EMOTTC), as antibacterial which is
one of the six compounds extracted from truffles. A number of organic
solvents have been used as CH3OH,C2H5OH, CHCl3, C4H8O2, and nC6H14. The highest percentage of the extract was obtained in the
extraction process when using methanol alcohol and the lowest
percentage when using chloroform.
Objective: The biological efficacy of (EMOTTC) was investigated
against different types of bacteria by taking higher Concentration of
this compound and the lowest concentration of the compound.
Materials and methods: The purpose of the manuscript was to study
bacterial inhibitory activity using MacConkey Agar as an agricultural
medium. (EMOTTC) showed excellent bioavailability against different
types of Gram-positive and positive bacteria. The EMOTTC compound
has a strong effect on pathogenic bacteria, especially Staphylococcus
aureus, Haemophilus influenzae, and Pseudomonas aeruginosa, which
indicates that this compound can have multiple drugs uses as an
alternative to antibiotics and sterilizers.
Results: Using the GC-Mas Spectrum technique, all the bio-organic
compounds were diagnosis in the organic layer of the extract, then
several methods were performed to determine the type and
concentration of each organic compound alone. Spectroscopy of
(EMOTTC) was studied, and its biological activity against Grampositive and Positive bacteria was studied.
Conclusions: Six compounds were detected in Truffle extraction by
GC-Mas technology. The same technique demonstrated the ability to
isolate (EMOTTC) using different solvents and the effect of this
biologically active compound was studied against three Types of
bacteria that cause eye infections and ophthalmia.

Key words: Truffles extract, EMOTTC phytochemical extracts, antibacterial activity


 
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How to Cite this Article
Pubmed Style

Rana D. S. ALkamil, Dawood CH. Al-Bahadily, Rasool Chaloob, Falah Hassan Shari, H. N. K. AL-Salman. Estimation of Truffles Extracts and Study the Biological Efficacy of Ethyl 6-methyl-2-oxo-4-(2-thienyl)-1,2,3,4- tetrahydropyrimidine-5-carboxylate (EMOTTC) as One of the Extracts against Ophthalmic Bacteria. SRP. 2020; 11(6): 878-887. doi:10.31838srp.2020.6.126


Web Style

Rana D. S. ALkamil, Dawood CH. Al-Bahadily, Rasool Chaloob, Falah Hassan Shari, H. N. K. AL-Salman. Estimation of Truffles Extracts and Study the Biological Efficacy of Ethyl 6-methyl-2-oxo-4-(2-thienyl)-1,2,3,4- tetrahydropyrimidine-5-carboxylate (EMOTTC) as One of the Extracts against Ophthalmic Bacteria. http://www.sysrevpharm.org//?mno=9990 [Access: July 02, 2020]. doi:10.31838srp.2020.6.126


AMA (American Medical Association) Style

Rana D. S. ALkamil, Dawood CH. Al-Bahadily, Rasool Chaloob, Falah Hassan Shari, H. N. K. AL-Salman. Estimation of Truffles Extracts and Study the Biological Efficacy of Ethyl 6-methyl-2-oxo-4-(2-thienyl)-1,2,3,4- tetrahydropyrimidine-5-carboxylate (EMOTTC) as One of the Extracts against Ophthalmic Bacteria. SRP. 2020; 11(6): 878-887. doi:10.31838srp.2020.6.126



Vancouver/ICMJE Style

Rana D. S. ALkamil, Dawood CH. Al-Bahadily, Rasool Chaloob, Falah Hassan Shari, H. N. K. AL-Salman. Estimation of Truffles Extracts and Study the Biological Efficacy of Ethyl 6-methyl-2-oxo-4-(2-thienyl)-1,2,3,4- tetrahydropyrimidine-5-carboxylate (EMOTTC) as One of the Extracts against Ophthalmic Bacteria. SRP. (2020), [cited July 02, 2020]; 11(6): 878-887. doi:10.31838srp.2020.6.126



Harvard Style

Rana D. S. ALkamil, Dawood CH. Al-Bahadily, Rasool Chaloob, Falah Hassan Shari, H. N. K. AL-Salman (2020) Estimation of Truffles Extracts and Study the Biological Efficacy of Ethyl 6-methyl-2-oxo-4-(2-thienyl)-1,2,3,4- tetrahydropyrimidine-5-carboxylate (EMOTTC) as One of the Extracts against Ophthalmic Bacteria. SRP, 11 (6), 878-887. doi:10.31838srp.2020.6.126



Turabian Style

Rana D. S. ALkamil, Dawood CH. Al-Bahadily, Rasool Chaloob, Falah Hassan Shari, H. N. K. AL-Salman. 2020. Estimation of Truffles Extracts and Study the Biological Efficacy of Ethyl 6-methyl-2-oxo-4-(2-thienyl)-1,2,3,4- tetrahydropyrimidine-5-carboxylate (EMOTTC) as One of the Extracts against Ophthalmic Bacteria. Systematic Reviews in Pharmacy, 11 (6), 878-887. doi:10.31838srp.2020.6.126



Chicago Style

Rana D. S. ALkamil, Dawood CH. Al-Bahadily, Rasool Chaloob, Falah Hassan Shari, H. N. K. AL-Salman. "Estimation of Truffles Extracts and Study the Biological Efficacy of Ethyl 6-methyl-2-oxo-4-(2-thienyl)-1,2,3,4- tetrahydropyrimidine-5-carboxylate (EMOTTC) as One of the Extracts against Ophthalmic Bacteria." Systematic Reviews in Pharmacy 11 (2020), 878-887. doi:10.31838srp.2020.6.126



MLA (The Modern Language Association) Style

Rana D. S. ALkamil, Dawood CH. Al-Bahadily, Rasool Chaloob, Falah Hassan Shari, H. N. K. AL-Salman. "Estimation of Truffles Extracts and Study the Biological Efficacy of Ethyl 6-methyl-2-oxo-4-(2-thienyl)-1,2,3,4- tetrahydropyrimidine-5-carboxylate (EMOTTC) as One of the Extracts against Ophthalmic Bacteria." Systematic Reviews in Pharmacy 11.6 (2020), 878-887. Print. doi:10.31838srp.2020.6.126



APA (American Psychological Association) Style

Rana D. S. ALkamil, Dawood CH. Al-Bahadily, Rasool Chaloob, Falah Hassan Shari, H. N. K. AL-Salman (2020) Estimation of Truffles Extracts and Study the Biological Efficacy of Ethyl 6-methyl-2-oxo-4-(2-thienyl)-1,2,3,4- tetrahydropyrimidine-5-carboxylate (EMOTTC) as One of the Extracts against Ophthalmic Bacteria. Systematic Reviews in Pharmacy, 11 (6), 878-887. doi:10.31838srp.2020.6.126





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