Interpretation of Full Scan Atmospheric Pressure Ionization Mass Spectra (MS) and Collision Induced Dissociation Fragmentation Spectra (MS/MS) of Small Organic Molecules – A Mini Review

Submitted by system on Wed, 12/21/2016 - 02:09
Systematic Reviews in Pharmacy,2017,8,1,48-51.
Published:December 2016
Type:Review Article

Interpretation of Full Scan Atmospheric Pressure Ionization Mass Spectra (MS) and Collision Induced Dissociation Fragmentation Spectra (MS/MS) of Small Organic Molecules – A Mini Review

Dev Kant Shandilya,1* Peter Edward Joseph,2 Venkata Siva Satyanarayana Kantamreddi3

1Department of Research, Bhagwant University, Ajmer, Rajasthan, INDIA

2Department of Chemistry, St. John’s College, Agra, Uttar Pradesh, INDIA

3Centre for Chemical Analysis, Central Research Laboratory (CRL), GIT, GITAM University, Visakhapatnam, INDIA

Abstract:

The potential of mass spectrometry (MS) is often not fully utilized due to the absence of systematic workflow of mass spectral interpretation, partially caused by the lack of simplified literature for interpretation of soft ionization methods and collision induced fragmentation spectral data interpretation. Therefore, this review summarizes the rational work flows for the interpretation of mass spectral data generated using atmospheric pressure ionization (API) and collision induced dissociation (CID) fragmentation. Designed workflow will definitely assist the readers to interpret MS and MS/MS spectral data, especially for the structural elucidation of small drug molecules and their impurities.

Images: 
Shandilya D. K