Gold (III) Complexes as Breast Cancer Drug

Submitted by system on Sat, 03/04/2017 - 02:55
Systematic Reviews in Pharmacy,2017,8,1,76-79.
Published:March 2016
Type:Review Article

Gold (III) Complexes as Breast Cancer Drug

Firas Hassan1, Salam Abd Al Qadeem Mohammed2*, Anil Philip3, Ayah Abdul Hameed1, Emad Yousif1

1Department of Chemistry, College of Science, Al-Nahrain University, Baghdad, IRAQ.

2Department of Chemical and Petrochemical Engineering, College of Engineering and Architecture, University of Nizwa, 616 Nizwa, Sultanate of Oman.

3College of Pharmacy and Nursing, University of Nizwa, 616, Nizwa, Sultanate of Oman.

Abstract:

Transition metals represent the d block element which includes groups 3-12 on the periodic table. Their d shells are in a process of filling. This property of these kinds of metals realized the foundation of coordination structures. Some of new gold (III) compounds have been prepared that are enough consistent under physiological conditions and are promising contender for pharmacological testing as cytotoxic and antitumor administrators. In vitro pharmacological studies point out that some of these novel gold (III) structures are astoundingly cytotoxic toward refined human tumor cell lines. Preliminary results on legitimate to DNA in vitro were exhibited, raising that the affiliations were generally slight. A few of Au (III) mixes with multi-dentate ligands such asen (ethylendiamine), dien (diethylendiamine) and sticky (N-benzyl-N, N-dimethylamine) have been seen to be dynamic against human tumor cell lines.

Images: 
The structure of [Au(bipy-H)(OH)]PF6