Traditional and Novel Methods for Cocrystal Formation: A Mini Review

Submitted by system on Wed, 04/18/2018 - 06:37
Systematic Reviews in Pharmacy,2018,9,1,79-82.
Published:April 2018
Type:Review Article

Traditional and Novel Methods for Cocrystal Formation: A Mini Review

Kuni Zu’aimah Barikah*

Department of Pharmaceutics, Faculty of Pharmacy, University of Jember, Kalimantan 37-68121, Jember, INDONESIA.

Abstract:

Pharmaceutical cocrystal is one of solid-state modification for drug substance, mainly for solubility improvement. Traditionally, cocrystal can be prepared by solvent evaporation method, grinding, and slurry method, but, every method has limitation for certain condition. The current trend for cocrystal formation uses the sophisticated method such as hot-melt extrusion method, spray drying method, supercritical fluid technology and the newest, and laser irradiation method. Development of new method is not only to overcome the limitation of traditional cocrystallization methods but also to generate a simpler step and continuous process for the production of cocrystal product. This article gives a brief explanation of each method that can be used to generate pharmaceutical cocrystals.