Vitamin D Supplementation in Patients with Iron Deficiency Anaemia: A Systematic Review and a Meta-Analysis

Systematic Reviews in Pharmacy,2018,10,1,01-10.
Published:December 2018
Type:Review Article

Vitamin D Supplementation in Patients with Iron Deficiency Anaemia: A Systematic Review and a Meta-Analysis

Roopa Satyanarayan Basutkar1, Tenzin Tsundue1, Hema Siva1, Anju Rose1, Sivasankaran Ponnusankar1,2*

1Department of Pharmacy Practice JSS College of Pharmacy, Udhagamandalam- 643 001, The Nilgiris, Tamilnadu, INDIA.

2JSS Academy of Higher Education and Research, Mysuru, Karnataka, INDIA.

Abstract:

Recent studies exhibit low Vitamin D levels and iron deficiency anemia condition co-exist, but evidence on the impact of vitamin D supplementation on iron deficiency anemia is lacking. The objectives of the review were to estimate the efficacy of vitamin D supplementation on patients with iron deficiency anemia. This review included the Randomized Controlled Trials from PubMed, IndMed and Cochrane Database of Systematic Reviews. Trials presenting vitamin D supplementation with control groups administered placebo and published in a peer-reviewed journal were considered eligible. Four trials were included for the primary outcome analysis. Vitamin D supplementation had no statistically significant impact on the outcomes of Hemoglobin {p< 0.18; I2: 36%; MD -0.05, 95% confidence interval (CI) -0.39 to 0.28} and Serum Ferritin {p< 0.18; I2: 36%; MD -0.05, 95% confidence interval (CI) -0.39 to 0.28} However, there was a statistically significant impact for serum Vitamin D levels by supplementation of vitamin D {p<0.00001; MD 17.28, 95% confidence interval (CI) 5.64 to 28.92}. As the results depicted in this review are inconclusive, further randomized controlled studies are required to strongly conclude whether supplementation of vitamin D improves iron deficiency.