Therapeutic Potential of Phytochemicals Isolated from Simarouba glauca DC for Inhibiting Cancers: A Review

Systematic Reviews in Pharmacy,2018,10,1,73-80.
Published:December 2018
Type:Review Article

Therapeutic Potential of Phytochemicals Isolated from Simarouba glauca DC for Inhibiting Cancers: A Review

Asha Jose1, Elango Kannan2, P.R. Anand Vijaya Kumar2, SubbaRao V. Madhunapantula3*

1DST-INSPIRE Research Fellow, Department of Pharmacology, JSS College of Pharmacy, Udhagamandalam-643001, Tamil Nadu, INDIA.

2Professor, Department of Pharmacology, JSS College of Pharmacy, Udhagamandalam-643001, Tamil Nadu, INDIA.

3Professor, Department of Biochemistry, Centre of Excellence in Molecular Biology and Regenerative Medicine, JSS Medical College, JSS Academy of Higher Education and Research, Mysore-570 015, Karnataka, INDIA.

Abstract:

Simarouba glauca DC (Family: Simaroubaceae, abbreviated as S. glauca / SG), commonly known as ‘Laxmitaru’ or ‘Paradise tree’ is an eco-friendly tree that grows in tropical areas of America, The West Indies and Brazil. Nutritionally, SG has been used as a potential source of edible oil. Medicinally, the decoction prepared from SG leaves has been demonstrated to exhibit antitumor, antimalarial, antiviral activities. Although pharmacological potential of Simarouba glauca is well documented; not much is known about the mechanism(s) of action of the isolated phytoconstituents. In addition, many gaps pertaining to the efficacy of pharmacological agents for inhibiting cancers does exist. Therefore, future studies should focus on (a) screening and isolating key pharmacological agents that exhibit better safety and efficacy profiles for treating cancers; (b) evaluating the pharmacodynamic and pharmacokinetic properties of phytochemicals in experimental animal models; (c) testing the compounds in clinical trials; and (d) developing better strategies to effectively deliver the isolated compounds from SG. Studies are also warranted to determine whether isolated compounds of SG are better or the crude extracts that contain a combination of agents are better. Addressing these research areas helps to prepare better formulations using SG extracts. Hence in this review, we have covered the literature pertaining to the anti-cancer agents isolated from SG and identified areas that require additional studies for better understanding of the pharmaceuticals agents.