E-ISSN 0976-2779 | ISSN 0975-8453
 

Review Article 


Therapeutic Efficacy of Bone Marrow- Derived Mesenchymal Stem Cells Plus Zinc Oxide Nanoparticles Against Streptozotocin- Induced Type 2 Diabetes in Albino Rats.

Khabat Anwar Ali.

Abstract
Diabetes mellitus (DM) is characterized by hyperglycemia which is often related with long-term complications, including retinopathy, nephropathy, and neuropathy, macro vascular and micro vascular damage. The current study was designed to evaluate the ability of bone marrow stem cells and ZnO nanoparticles to ameliorate the disturbances in some physiological parameters induced by DM in rats. Histological studied on the pancreas were also involved. Forty-two male albino rats were divided into seven groups, (n = 6 per group). Four of the groups were induced with diabetes by a single intraperitoneal injection of freshly prepared streptozotocin at a dose of 50 mg/kg body weight. After the induction of diabetes, the rats were treated with MSCs a single dose of (106cells per rat) and ZnO nanoparticles (10mg/kg) separately and in combination daily for 4 weeks, whereas, one of the diabetic groups served as a positive control. The blood glucose, serum insulin, pancreatic malondialdehyde (MDA), total antioxidant capacity (TAC) and interleukin-10(IL-10) levels were determined. Diabetic rats demonstrated a significant increase in plasma levels of glucose, pancreatic MDA and IL-10. In contrast, levels of plasma insulin and TAC in pancreas decreased significantly in diabetic rats compared to the control rats. Hence, diabetic rats treated with MSCs and ZnONPs in combination showed maximum improvements with respect to the indices in addition to a significant recovery observed by histopathological study when compared to the diabetic group.
Conclusions: These results revealed that treatment with MSCs in combination with ZnONPs in diabetic rats was more effective than treatment with either of MSCs or ZnONPs alone to alleviate the symptoms of diabetic mellitus

Key words: Type 2 diabetes mellitus, bone marrow mesenchymal stem cells, ZnO nanoparticles, streptozotocin, Pancreas


 
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Pubmed Style

Khabat Anwar Ali. Therapeutic Efficacy of Bone Marrow- Derived Mesenchymal Stem Cells Plus Zinc Oxide Nanoparticles Against Streptozotocin- Induced Type 2 Diabetes in Albino Rats.. SRP. 2020; 11(5): 40-51. doi:10.31838/srp.2020.5.08


Web Style

Khabat Anwar Ali. Therapeutic Efficacy of Bone Marrow- Derived Mesenchymal Stem Cells Plus Zinc Oxide Nanoparticles Against Streptozotocin- Induced Type 2 Diabetes in Albino Rats.. http://www.sysrevpharm.org//?mno=106526 [Access: May 25, 2020]. doi:10.31838/srp.2020.5.08


AMA (American Medical Association) Style

Khabat Anwar Ali. Therapeutic Efficacy of Bone Marrow- Derived Mesenchymal Stem Cells Plus Zinc Oxide Nanoparticles Against Streptozotocin- Induced Type 2 Diabetes in Albino Rats.. SRP. 2020; 11(5): 40-51. doi:10.31838/srp.2020.5.08



Vancouver/ICMJE Style

Khabat Anwar Ali. Therapeutic Efficacy of Bone Marrow- Derived Mesenchymal Stem Cells Plus Zinc Oxide Nanoparticles Against Streptozotocin- Induced Type 2 Diabetes in Albino Rats.. SRP. (2020), [cited May 25, 2020]; 11(5): 40-51. doi:10.31838/srp.2020.5.08



Harvard Style

Khabat Anwar Ali (2020) Therapeutic Efficacy of Bone Marrow- Derived Mesenchymal Stem Cells Plus Zinc Oxide Nanoparticles Against Streptozotocin- Induced Type 2 Diabetes in Albino Rats.. SRP, 11 (5), 40-51. doi:10.31838/srp.2020.5.08



Turabian Style

Khabat Anwar Ali. 2020. Therapeutic Efficacy of Bone Marrow- Derived Mesenchymal Stem Cells Plus Zinc Oxide Nanoparticles Against Streptozotocin- Induced Type 2 Diabetes in Albino Rats.. Systematic Reviews in Pharmacy, 11 (5), 40-51. doi:10.31838/srp.2020.5.08



Chicago Style

Khabat Anwar Ali. "Therapeutic Efficacy of Bone Marrow- Derived Mesenchymal Stem Cells Plus Zinc Oxide Nanoparticles Against Streptozotocin- Induced Type 2 Diabetes in Albino Rats.." Systematic Reviews in Pharmacy 11 (2020), 40-51. doi:10.31838/srp.2020.5.08



MLA (The Modern Language Association) Style

Khabat Anwar Ali. "Therapeutic Efficacy of Bone Marrow- Derived Mesenchymal Stem Cells Plus Zinc Oxide Nanoparticles Against Streptozotocin- Induced Type 2 Diabetes in Albino Rats.." Systematic Reviews in Pharmacy 11.5 (2020), 40-51. Print. doi:10.31838/srp.2020.5.08



APA (American Psychological Association) Style

Khabat Anwar Ali (2020) Therapeutic Efficacy of Bone Marrow- Derived Mesenchymal Stem Cells Plus Zinc Oxide Nanoparticles Against Streptozotocin- Induced Type 2 Diabetes in Albino Rats.. Systematic Reviews in Pharmacy, 11 (5), 40-51. doi:10.31838/srp.2020.5.08





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