E-ISSN 0976-2779 | ISSN 0975-8453
 

Review Article 


Impact of Omega-3 on Hypercholesteremia Induced Male Rabbits

Fadhil A. Rizij, Ali M. Janabi, Ayad A. Ameen, Najah R. Hadi.

Abstract
Atherosclerosis is a disorder of vasculature wall resulting mainly from the inflammatory processes. This condition involves vascular endothelial dysfunction, recruitment and activation of phagocytic cells in early stages. Omega-3 polyunsaturated fatty acids comprise part of the cellular membrane function many roles including increased development and functionality of neuronal synapses. This study assesses the significance of omega-3 fatty acids on atherosclerosis events via lowering oxidative and inflammatory insults. In this study, twenty-four domestic rabbits (male) were randomly distributed into three groups. The first one was the negative control group in which, rabbits were received normal diet (Oxide) for twelve week-period. The second group was the hypercholesteremia-induced, untreated rabbits fed with cholesterol (1%) enriched diet. The third group consumed cholesterol (1%) enriched diet supplemented with 5% omega-3 fatty acids. Blood samples were collected after twelve weeks to measure high-density lipoprotein-C (HDL-C), total cholesterol (TC), serum triglycerides (TG), endothelin-1 (ET-1), intracellular adhesion molecule-1 (ICAM-1) and highly sensitive C-reactive protein (hs-CRP) levels. After twelve weeks, aorta of each rabbit was isolated to identify glutathione (GSH),malondialdehyde (MDA) and intimal thickness. Administration of omega-3 was un-capable to modify lipid parameters significantly when compared with high cholesterol-fed rabbits. Administration of omega-3 results in improvement of ICAM-1, hs-CRP, ET-1, aortic MDA and intimal thickness of aorta significantly when compared with untreated high cholesterol-fed rabbits (P<0.05), Aortic GSH level was restored in rabbits receiving omega-3 fatty acids (P<0.05). Omega-3 fatty acid may reduce atherosclerosis progression in high cholesterol-fed rabbits via suppression of inflammatory and oxidative cascades with the lack of impacting of lipid profile.

Key words: Omega 3 fatty acid, intracellular adhesion molecule-1, endothelin-1, aortic intimal thickness, oxidative stress, atherosclerosis.


 
ARTICLE TOOLS
Abstract
PDF Fulltext
How to cite this articleHow to cite this article
Citation Tools
Related Records
 Articles by Fadhil A. Rizij
Articles by Ali M. Janabi
Articles by Ayad A. Ameen
Articles by Najah R. Hadi
on Google
on Google Scholar


How to Cite this Article
Pubmed Style

Fadhil A. Rizij, Ali M. Janabi, Ayad A. Ameen, Najah R. Hadi. Impact of Omega-3 on Hypercholesteremia Induced Male Rabbits. SRP. 2020; 11(5): 70-74. doi:10.31838/srp.2020.5.12


Web Style

Fadhil A. Rizij, Ali M. Janabi, Ayad A. Ameen, Najah R. Hadi. Impact of Omega-3 on Hypercholesteremia Induced Male Rabbits. http://www.sysrevpharm.org//?mno=106837 [Access: May 25, 2020]. doi:10.31838/srp.2020.5.12


AMA (American Medical Association) Style

Fadhil A. Rizij, Ali M. Janabi, Ayad A. Ameen, Najah R. Hadi. Impact of Omega-3 on Hypercholesteremia Induced Male Rabbits. SRP. 2020; 11(5): 70-74. doi:10.31838/srp.2020.5.12



Vancouver/ICMJE Style

Fadhil A. Rizij, Ali M. Janabi, Ayad A. Ameen, Najah R. Hadi. Impact of Omega-3 on Hypercholesteremia Induced Male Rabbits. SRP. (2020), [cited May 25, 2020]; 11(5): 70-74. doi:10.31838/srp.2020.5.12



Harvard Style

Fadhil A. Rizij, Ali M. Janabi, Ayad A. Ameen, Najah R. Hadi (2020) Impact of Omega-3 on Hypercholesteremia Induced Male Rabbits. SRP, 11 (5), 70-74. doi:10.31838/srp.2020.5.12



Turabian Style

Fadhil A. Rizij, Ali M. Janabi, Ayad A. Ameen, Najah R. Hadi. 2020. Impact of Omega-3 on Hypercholesteremia Induced Male Rabbits. Systematic Reviews in Pharmacy, 11 (5), 70-74. doi:10.31838/srp.2020.5.12



Chicago Style

Fadhil A. Rizij, Ali M. Janabi, Ayad A. Ameen, Najah R. Hadi. "Impact of Omega-3 on Hypercholesteremia Induced Male Rabbits." Systematic Reviews in Pharmacy 11 (2020), 70-74. doi:10.31838/srp.2020.5.12



MLA (The Modern Language Association) Style

Fadhil A. Rizij, Ali M. Janabi, Ayad A. Ameen, Najah R. Hadi. "Impact of Omega-3 on Hypercholesteremia Induced Male Rabbits." Systematic Reviews in Pharmacy 11.5 (2020), 70-74. Print. doi:10.31838/srp.2020.5.12



APA (American Psychological Association) Style

Fadhil A. Rizij, Ali M. Janabi, Ayad A. Ameen, Najah R. Hadi (2020) Impact of Omega-3 on Hypercholesteremia Induced Male Rabbits. Systematic Reviews in Pharmacy, 11 (5), 70-74. doi:10.31838/srp.2020.5.12





Most Viewed Articles
  • Dental Development between Assisted Reproductive Therapy (Art) and Natural Conceived Children: A Comparative Pilot Study
    Norzaiti Mohd Kenali, Naimah Hasanah Mohd Fathil, Norbasyirah Bohari, Ahmad Faisal Ismail, Roszaman Ramli
    SRP. 2020; 11(1): 01-06
    » Abstract » doi: 10.5530/srp.2020.1.01

  • Psychometric properties of the World Health Organization Quality of life instrument, short form: Validity in the Vietnamese healthcare context
    Trung Quang Vo*, Bao Tran Thuy Tran, Ngan Thuy Nguyen, Tram ThiHuyen Nguyen, Thuy Phan Chung Tran
    SRP. 2020; 11(1): 14-22
    » Abstract » doi: 10.5530/srp.2020.1.03

  • A Prospective Review on Phyto-Pharmacological Aspects of Andrographis paniculata
    Govindraj Akilandeswari, Arumugam Vijaya Anand, Palanisamy Sampathkumar, Puthamohan Vinayaga Moorthi, Basavaraju Preethi
    SRP. 2019; 10(1): 15-19
    » Abstract » doi: 10.5530/srp.2019.1.3

  • A Review of Pharmacoeconomics: the key to “Healthcare for All”
    Hasamnis AA, Patil SS, Shaik Imam, Narendiran K
    SRP. 2019; 10(1): s40-s42
    » Abstract » doi: 10.5530/srp.2019.1s.21

  • Deuterium Depleted Water as an Adjuvant in Treatment of Cancer
    Anton Syroeshkin, Olga Levitskaya, Elena Uspenskaya, Tatiana Pleteneva, Daria Romaykina, Daria Ermakova
    SRP. 2019; 10(1): 112-117
    » Abstract » doi: 10.5530/srp.2019.1.19

  • Most Downloaded
  • Dental Development between Assisted Reproductive Therapy (Art) and Natural Conceived Children: A Comparative Pilot Study
    Norzaiti Mohd Kenali, Naimah Hasanah Mohd Fathil, Norbasyirah Bohari, Ahmad Faisal Ismail, Roszaman Ramli
    SRP. 2020; 11(1): 01-06
    » Abstract » doi: 10.5530/srp.2020.1.01

  • Manilkara zapota (L.) Royen Fruit Peel: A Phytochemical and Pharmacological Review
    Karle Pravin P, Dhawale Shashikant C
    SRP. 2019; 10(1): 11-14
    » Abstract » doi: 0.5530/srp.2019.1.2

  • Pharmacognostic and Phytopharmacological Overview on Bombax ceiba
    Pankaj Haribhau Chaudhary, Mukund Ganeshrao Tawar
    SRP. 2019; 10(1): 20-25
    » Abstract » doi: 10.5530/srp.2019.1.4

  • A Review of Pharmacoeconomics: the key to “Healthcare for All”
    Hasamnis AA, Patil SS, Shaik Imam, Narendiran K
    SRP. 2019; 10(1): s40-s42
    » Abstract » doi: 10.5530/srp.2019.1s.21

  • A Prospective Review on Phyto-Pharmacological Aspects of Andrographis paniculata
    Govindraj Akilandeswari, Arumugam Vijaya Anand, Palanisamy Sampathkumar, Puthamohan Vinayaga Moorthi, Basavaraju Preethi
    SRP. 2019; 10(1): 15-19
    » Abstract » doi: 10.5530/srp.2019.1.3

  • Most Cited Articles