E-ISSN 0976-2779 | ISSN 0975-8453
 

Review Article 


Determination and Evaluation of Doses of Metronidazole in Different Quantities and Formulations with Multiple Spectroscopic Methods

Khawla Salman Abd-Alrassol, H. N. K. AL-Salman, Ekhlas Qanber Jasim, Hussein H. Hussein.

Abstract
Three quick and sensitive spectrum methods have been suggested to determine Metronidazole. All spectral methods that were used included reducing Metronidazole by mixing zinc powder with hydrochloric acid. The first method (A) included the process of the conjugation of resorcinol reagent with metronidazole and the production of red chromophores, which was then estimated spectrally at a maximum wavelength of 520 nm.
Method–B including the reaction p-chloro benzaldihyde in acidic medium to product yellow color Schiff base has an absorbance at 305 nm. The method C employing a charge transfer reaction with hydroquinone accepter in basic medium to product orange to yellow product absorbed at 335 nm. The best experimental conditions were used by applying the beer's Law for a range of concentrations 2.0-50 μg ml-1, 1.0-35 μg ml-1 and 1.5-30 μg ml-1for methods A, B and C respectively, and the corresponding molar absorptivity values are 1.375×104, 8.672×104, 1.995×104 L mol-1cm-1 with a Correlation coefficient of 0.9996, 0.9998, and 0.9988 and Limits Of Detection (LOD) 0.145 μg ml-1, 0.0776 μg ml-1and 0.110 μg ml-1 and Limits of Quantitation (LOQ) 0.4412 μg ml-1, 0.2352 μg ml-1and 0.3333 μg ml-1 for methods A, B and C Sequentially. The methods were successfully applied to the determination of Metronidazole in pharmaceutical preparation.

Key words: Metronidazole drug, Diazotation and coupling reaction, Schiff base, Ion pair complex, Spectrophotometric methods.


 
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How to Cite this Article
Pubmed Style

Khawla Salman Abd-Alrassol, H. N. K. AL-Salman, Ekhlas Qanber Jasim, Hussein H. Hussein. Determination and Evaluation of Doses of Metronidazole in Different Quantities and Formulations with Multiple Spectroscopic Methods. SRP. 2020; 11(5): 130-139. doi:10.31838/srp.2020.5.21


Web Style

Khawla Salman Abd-Alrassol, H. N. K. AL-Salman, Ekhlas Qanber Jasim, Hussein H. Hussein. Determination and Evaluation of Doses of Metronidazole in Different Quantities and Formulations with Multiple Spectroscopic Methods. http://www.sysrevpharm.org//?mno=108396 [Access: May 25, 2020]. doi:10.31838/srp.2020.5.21


AMA (American Medical Association) Style

Khawla Salman Abd-Alrassol, H. N. K. AL-Salman, Ekhlas Qanber Jasim, Hussein H. Hussein. Determination and Evaluation of Doses of Metronidazole in Different Quantities and Formulations with Multiple Spectroscopic Methods. SRP. 2020; 11(5): 130-139. doi:10.31838/srp.2020.5.21



Vancouver/ICMJE Style

Khawla Salman Abd-Alrassol, H. N. K. AL-Salman, Ekhlas Qanber Jasim, Hussein H. Hussein. Determination and Evaluation of Doses of Metronidazole in Different Quantities and Formulations with Multiple Spectroscopic Methods. SRP. (2020), [cited May 25, 2020]; 11(5): 130-139. doi:10.31838/srp.2020.5.21



Harvard Style

Khawla Salman Abd-Alrassol, H. N. K. AL-Salman, Ekhlas Qanber Jasim, Hussein H. Hussein (2020) Determination and Evaluation of Doses of Metronidazole in Different Quantities and Formulations with Multiple Spectroscopic Methods. SRP, 11 (5), 130-139. doi:10.31838/srp.2020.5.21



Turabian Style

Khawla Salman Abd-Alrassol, H. N. K. AL-Salman, Ekhlas Qanber Jasim, Hussein H. Hussein. 2020. Determination and Evaluation of Doses of Metronidazole in Different Quantities and Formulations with Multiple Spectroscopic Methods. Systematic Reviews in Pharmacy, 11 (5), 130-139. doi:10.31838/srp.2020.5.21



Chicago Style

Khawla Salman Abd-Alrassol, H. N. K. AL-Salman, Ekhlas Qanber Jasim, Hussein H. Hussein. "Determination and Evaluation of Doses of Metronidazole in Different Quantities and Formulations with Multiple Spectroscopic Methods." Systematic Reviews in Pharmacy 11 (2020), 130-139. doi:10.31838/srp.2020.5.21



MLA (The Modern Language Association) Style

Khawla Salman Abd-Alrassol, H. N. K. AL-Salman, Ekhlas Qanber Jasim, Hussein H. Hussein. "Determination and Evaluation of Doses of Metronidazole in Different Quantities and Formulations with Multiple Spectroscopic Methods." Systematic Reviews in Pharmacy 11.5 (2020), 130-139. Print. doi:10.31838/srp.2020.5.21



APA (American Psychological Association) Style

Khawla Salman Abd-Alrassol, H. N. K. AL-Salman, Ekhlas Qanber Jasim, Hussein H. Hussein (2020) Determination and Evaluation of Doses of Metronidazole in Different Quantities and Formulations with Multiple Spectroscopic Methods. Systematic Reviews in Pharmacy, 11 (5), 130-139. doi:10.31838/srp.2020.5.21





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