E-ISSN 0976-2779 | ISSN 0975-8453
 

Review Article 


Vitamin D Supplementation in Patients with Iron Deficiency Anaemia: A Systematic Review and a Meta-Analysis

Roopa Satyanarayan Basutkar, Tenzin Tsundue, Hema Siva, Anju Rose, Sivasankaran Ponnusankar.

Abstract
Recent studies exhibit low Vitamin D levels and iron deficiency anemia
condition co-exist, but evidence on the impact of vitamin D supplementation on iron deficiency anemia is lacking. The objectives of the review were to estimate the efficacy of vitamin D supplementation on patients with iron deficiency anemia. This review included the Randomized Controlled Trials from PubMed, IndMed and Cochrane Database of Systematic Reviews.
Trials presenting vitamin D supplementation with control groups administered placebo and published in a peer-reviewed journal were considered eligible. Four trials were included for the primary outcome analysis. Vitamin D supplementation had no statistically significant impact on the outcomes of Hemoglobin {p< 0.18; I2: 36%; MD -0.05, 95% confidence interval (CI)
-0.39 to 0.28} and Serum Ferritin {p< 0.18; I2: 36%; MD -0.05, 95% confidence interval (CI) -0.39 to 0.28} However, there was a statistically significant impact for serum Vitamin D levels by supplementation of vitamin D
{p<0.00001; MD 17.28, 95% confidence interval (CI) 5.64 to 28.92}. As
the results depicted in this review are inconclusive, further randomized controlled studies are required to strongly conclude whether supplementation
of vitamin D improves iron deficiency.
SYSTEMATIC REVIEW REGISTRATION
Prospero registration number: CRD42018082004.

Key words: Hemoglobin, Serum Ferritin, Serum Vitamin D, Supplementation, Randomized controlled trials.


 
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How to Cite this Article
Pubmed Style

Roopa Satyanarayan Basutkar, Tenzin Tsundue, Hema Siva, Anju Rose, Sivasankaran Ponnusankar. Vitamin D Supplementation in Patients with Iron Deficiency Anaemia: A Systematic Review and a Meta-Analysis. SRP. 2019; 10(1): 1-10. doi:10.5530/srp.2019.1.1


Web Style

Roopa Satyanarayan Basutkar, Tenzin Tsundue, Hema Siva, Anju Rose, Sivasankaran Ponnusankar. Vitamin D Supplementation in Patients with Iron Deficiency Anaemia: A Systematic Review and a Meta-Analysis. http://www.sysrevpharm.org//?mno=302644527 [Access: February 25, 2020]. doi:10.5530/srp.2019.1.1


AMA (American Medical Association) Style

Roopa Satyanarayan Basutkar, Tenzin Tsundue, Hema Siva, Anju Rose, Sivasankaran Ponnusankar. Vitamin D Supplementation in Patients with Iron Deficiency Anaemia: A Systematic Review and a Meta-Analysis. SRP. 2019; 10(1): 1-10. doi:10.5530/srp.2019.1.1



Vancouver/ICMJE Style

Roopa Satyanarayan Basutkar, Tenzin Tsundue, Hema Siva, Anju Rose, Sivasankaran Ponnusankar. Vitamin D Supplementation in Patients with Iron Deficiency Anaemia: A Systematic Review and a Meta-Analysis. SRP. (2019), [cited February 25, 2020]; 10(1): 1-10. doi:10.5530/srp.2019.1.1



Harvard Style

Roopa Satyanarayan Basutkar, Tenzin Tsundue, Hema Siva, Anju Rose, Sivasankaran Ponnusankar (2019) Vitamin D Supplementation in Patients with Iron Deficiency Anaemia: A Systematic Review and a Meta-Analysis. SRP, 10 (1), 1-10. doi:10.5530/srp.2019.1.1



Turabian Style

Roopa Satyanarayan Basutkar, Tenzin Tsundue, Hema Siva, Anju Rose, Sivasankaran Ponnusankar. 2019. Vitamin D Supplementation in Patients with Iron Deficiency Anaemia: A Systematic Review and a Meta-Analysis. Systematic Reviews in Pharmacy, 10 (1), 1-10. doi:10.5530/srp.2019.1.1



Chicago Style

Roopa Satyanarayan Basutkar, Tenzin Tsundue, Hema Siva, Anju Rose, Sivasankaran Ponnusankar. "Vitamin D Supplementation in Patients with Iron Deficiency Anaemia: A Systematic Review and a Meta-Analysis." Systematic Reviews in Pharmacy 10 (2019), 1-10. doi:10.5530/srp.2019.1.1



MLA (The Modern Language Association) Style

Roopa Satyanarayan Basutkar, Tenzin Tsundue, Hema Siva, Anju Rose, Sivasankaran Ponnusankar. "Vitamin D Supplementation in Patients with Iron Deficiency Anaemia: A Systematic Review and a Meta-Analysis." Systematic Reviews in Pharmacy 10.1 (2019), 1-10. Print. doi:10.5530/srp.2019.1.1



APA (American Psychological Association) Style

Roopa Satyanarayan Basutkar, Tenzin Tsundue, Hema Siva, Anju Rose, Sivasankaran Ponnusankar (2019) Vitamin D Supplementation in Patients with Iron Deficiency Anaemia: A Systematic Review and a Meta-Analysis. Systematic Reviews in Pharmacy, 10 (1), 1-10. doi:10.5530/srp.2019.1.1





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