Abstract

Fiki Muhammad Ridho55197*

Cancer is a disease characterized by cells that experience abnormal and uncontrolled mechanisms in regulating cell proliferation, differentiation, and apoptosis. According to the Indonesian Basic Health Research in 2018, the prevalence of cancer in Indonesia is still high, namely 1.79 per 1000. One of the treatments for cancer is chemotheraphy, but it has side effects that can reduce the patient’s quality of life. Therefore, researcher conducted further research on alternative medicine using extract of Bajakah (Uncaria nervosa Elmer). This study used the systematic literature review method with 5 journals obtained from the Science- Direct, PubMed, and Google Scholar databases. The results showed that the the types of alkaloids in the wood extract of Bajakah were rhynchophylline and isorhynchophylline, the most abundant types of flavonoids were flavanols and flavonols, and the most abundant types of terpenoids were ursan. The mechanism of action of alkaloids and flavonoids in general is to induce apoptosis through Tumor Necrosis Factor Receptors (TNFR). Flavonoids, isorhynchophylline, and ursan induce Bax and Bak. Isorhynchophylline and ursan suppress B-cell lymphoma 2 (Bcl-2) and B-cell lymphoma-extra large (Bcl-xL) expression. Also rhynchophylline and isorhynchophylline increase p53 signaling.