Abstract

Julliyan Dilleban58948*, Thenraja58949 and Sundaresan58950

This review article provides an overview of the use of Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) in orthopedics, including their pharmacology, efficacy, safety, use in various ortho-related conditions, and potential adverse effects. In orthopedic departments, NSAIDs are frequently prescribed to treat pain and inflammation caused by a variety of disorders such as osteoarthritis, rheumatoid arthritis, acute injuries, bursitis, tendonitis, gout, lower back pain, and surgeries. NSAIDs work by inhibiting the enzymes that produce prostaglandins, which are mediators of pain and inflammation. Though generally safe and effective, NSAIDs have major concerns over their potential side effects such as Gastro-Intestinal (GI) complications, cardiovascular complications, renal toxicity, and impairment in bone healing. This article explores the basic pharmacology of NSAIDs and the safety profile of NSAIDs in orthopedics, including the potential risks associated with their use. The article concludes that while NSAIDs are considered safe, there are potential risks associated with their use, and clinicians should carefully consider the risks and benefits of NSAID therapy and take steps to mitigate potential adverse effects.