Abstract

Sara Zahid55863, Fatima Zahid55864, Faisal Gulzar55865, Qurban Ali55866, Ayesha Zahid55867 and Arif Malik55868*

Three dimensional bioprinting has been the cutting edge of tissue engineering research that has shown the tremendous potential of fabricating customized desired 3D tissue model only of its appropriate size and dimension. The combination of different nanomaterials with dimensional scales and the 3D bioprinting technologies enabled the manufacturing of various transplantable tissue scaffolds such as multilayered skin, bone, vascular grafts, cardiac tissues, tracheal splints, skull bone and cartilaginous structures with unique, physical, chemical and biological properties similar to the native structure for the treatment of osteosarcoma, cancer bone metastasis, breast cancer and inflammatory diseases as well as tissue regeneration. The exploration of the implications of nanoparticles in engineering bone scaffolds have just commenced and have revealed tremendous growth in the clinical efficacy of 3D bioprinted tissue scaffolds. In this review, we have discussed briefly the integration of nanotechnology and nanobiomaterials with 3D bioprinted tissue engineered scaffolds for engineering tissue and organ implants and the mechanism of 3D printing nanotechnology in addition of various 3D bioprinting strategies.