A Review on Role of Essential Oil as Penetration Enhancer in Transdermal Drug Delivery System

Abstract

Ataul Hasan, Heena Farooqui*

The use of essential oils and their constituents as skin penetration enhancers for transdermal drug delivery, as well as the mode of action and potential toxicity. Essential oils and their toxic components have the ability to penetrate the skin and improve the penetration of various drugs from topical formulations into the lower skin layers by various modes of action. (1) disintegration of the highly organised intercellular lipid structure between corneocytes in the Stratum Corneum, (2) association with the intercellular domain of proteins, causing conformational change, and (3) Increase a drug's partitioning essential oils and their components are easily metabolised, do not persist in the body, and are quickly excreted after application to the skin, indicating that they can be used as healthy penetration enhancers. Essential oils and their constituents can be preferable to synthetics as healthy and effective permeation enhancers for promoting the percutaneous absorption of hydrophilic and lipophilic drugs from topical formulations into the lower skin layers. they have been used successfully as secure penetration enhancers. To address these issues, the Transdermal Drug Delivery System (TDDS) was developed, which would increase the clinical effectiveness and safety of medications by allowing for more accurate (i.e., location specific) positioning inside the body, minimising both the size and number of doses. Many medications are now taken orally, but they are not as successful as they can be. This article offers a description of the transdermal drug delivery mechanism and forms of transdermal patches, as well as the use of polymer as a Transdermal Drug Delivery System, preparation processes, and physicochemical assessment methods and the various forms of transdermal systems currently on the market, with an emphasis on recent developments in Transdermal Drug Delivery Systems, which may serve as a forum for prescription drug dosage form research and development for Transdermal Drug Delivery.

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