Abstract

Gaurav Kant Saraogi74579, Seemu Singh74580, Arshita Kumari74581* and Rajeshwar Prajapati74582

Chemotherapy is one of the important components of treatment for many cancers. Anti-neoplastic agents are used with caution due to their high toxicity and narrow therapeutic window. Studies describing pattern of adverse drug reactions in cancer chemotherapy patients are less in India. This study aims to evaluate the pattern of Adverse Drug Reactions (ADRs) due to cancer chemotherapy in hospitalized patients and to assess the causality and severity of these reactions. This hospital-based prospective observational study was conducted at Sri Aurobindo Hospital, Indore, Madhya Pradesh among the newly diagnosed cases of different type of cancers of both genders between the ages of (25-70) years who required chemotherapy treatment. The prescribing pattern of chemotherapy drugs associated adverse effects and potential risk factors for the development of adverse effects was studied. An ADR causality was assessed by the World Health Organization-Uppsala Monitoring Centre (WHO-UMC) Naranjo algorithm was used to identify the predictors related to chemotherapy-induced adverse effects. Most common ADR observed were peripheral neuropathy, shivering, anemia, neutropenia, thrombocytopenia and needle phobia. In this study, gastric cancer was most commonly seen followed by esophageal cancer.