An Insight into Pyrazolo scaffold as anticancer

Abstract

Mazin A.A. Najm, Khulood H. Oudah, Wassan Nori Mohammed Hassan and Ali B. Roomi.

Cancer is caused by the uncontrolled development of abnormal cells, a severe and life-threatening health problem globally. It is a collection of various diseases kept referring to as perhaps the deadliest after cardiovascular disease in terms of lives lost. Despite large and innovative effective innovations to cancer issues, there are still gaps in cancer treatment; it is predicted to be the leading cause of death in the new millennium. Today, pharmaceutical manufacturing costs billions of dollars to discover effective, safe, and reliable cancer drugs in particular pyrazole derivatives. Pyrazole is a heterocyclic heterogeneous ring containing five adjacent atoms of nitrogen C3H3N2H. Interestingly, these scaffolds are present in the pharmacokinetics of various therapeutic classes, such as pyrazole pyrimidines, Known as adenine biotic, which is essential for all aspects of cell survival. Pyrazolo[1,5-a] pyrimidine have been investigated for their inhibitory potential against a diverse array of protein kinase enzymes and with their part as an anticancer drug. This study primarily addresses the artificial and anticancer activity of various pyrazole scaffolds, in particular pyrazole pyrimidine scaffolds.