Anticancer and apoptotic activities of SIRT1 activators through cell cycle arrest in Capan-2 human pancreatic carcinoma cell lines
Abstract
Inam Sameh Arif
A lot of novel SIRT1 activators were synthesized and estimated for their antitumor activities on pancreatic cancer cell lines, apoptosis induction, and cell cycle effects, but they contain side effects, non-direct binding to SIRT1 and high toxicity. There is, therefore, a need to develop selective and relatively non-toxic treatment regimens directed to activate SIRT1 at reducing the morbidity and mortality associated with pancreatic cancer. SIRT1 aptamer was originally designed for use in cancer treatment. However, the anti-cancer effects and the action mechanisms of SIRT1 aptamer remain elusive. In current study, the effects of SIRT1 aptamer at different concentration on the growth of human pancreatic cancer cells (Capan-2) were evaluated by study the cell apoptosis and cell cycle arrest. Taken together, the results indicated that SIRT1 aptamer induced apoptosis and cause cell cycle arrest in the S phase and could be a promising source for developing natural therapeutics for pancreatic cancer.
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| Pubmed Style Inam Sameh Arif. Anticancer and apoptotic activities of SIRT1 activators through cell cycle arrest in Capan-2 human pancreatic carcinoma cell lines. SRP. 2020; 11(11): 1001-1004. doi:10.31838/srp.2020.11.144 Web Style Inam Sameh Arif. Anticancer and apoptotic activities of SIRT1 activators through cell cycle arrest in Capan-2 human pancreatic carcinoma cell lines. http://www.sysrevpharm.org/?mno=18864 [Access: March 30, 2021]. doi:10.31838/srp.2020.11.144 AMA (American Medical Association) Style Inam Sameh Arif. Anticancer and apoptotic activities of SIRT1 activators through cell cycle arrest in Capan-2 human pancreatic carcinoma cell lines. SRP. 2020; 11(11): 1001-1004. doi:10.31838/srp.2020.11.144 Vancouver/ICMJE Style Inam Sameh Arif. Anticancer and apoptotic activities of SIRT1 activators through cell cycle arrest in Capan-2 human pancreatic carcinoma cell lines. SRP. (2020), [cited March 30, 2021]; 11(11): 1001-1004. doi:10.31838/srp.2020.11.144 Harvard Style Inam Sameh Arif (2020) Anticancer and apoptotic activities of SIRT1 activators through cell cycle arrest in Capan-2 human pancreatic carcinoma cell lines. SRP, 11 (11), 1001-1004. doi:10.31838/srp.2020.11.144 Turabian Style Inam Sameh Arif. 2020. Anticancer and apoptotic activities of SIRT1 activators through cell cycle arrest in Capan-2 human pancreatic carcinoma cell lines. Systematic Reviews in Pharmacy, 11 (11), 1001-1004. doi:10.31838/srp.2020.11.144 Chicago Style Inam Sameh Arif. "Anticancer and apoptotic activities of SIRT1 activators through cell cycle arrest in Capan-2 human pancreatic carcinoma cell lines." Systematic Reviews in Pharmacy 11 (2020), 1001-1004. doi:10.31838/srp.2020.11.144 MLA (The Modern Language Association) Style Inam Sameh Arif. "Anticancer and apoptotic activities of SIRT1 activators through cell cycle arrest in Capan-2 human pancreatic carcinoma cell lines." Systematic Reviews in Pharmacy 11.11 (2020), 1001-1004. Print. doi:10.31838/srp.2020.11.144 APA (American Psychological Association) Style Inam Sameh Arif (2020) Anticancer and apoptotic activities of SIRT1 activators through cell cycle arrest in Capan-2 human pancreatic carcinoma cell lines. Systematic Reviews in Pharmacy, 11 (11), 1001-1004. doi:10.31838/srp.2020.11.144 |
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