Antihyperglycemic and Antihyperlipidemic Effects of Methanolic Seeds Extract of Pandanus odoratissimus in Alloxan-Induced Diabetic Rats

Abstract

Sri Endarti Rahayu

Diabetes mellitus is one of the most serious diseases affecting a larger global population, accompanied with other long-term complications. Also, the management is this disease comes with various side effects, hence, the need for substances with little or no side effect. Therefore, this study aimed at evaluating the antidiabetic and antihyperlipidemic effects of methanolic extract of Pandanus odoratissimus seeds in alloxan-iduced diabetic rats. 30 adult male rats (Sprague Dawley) weighing 180-220 g were randomly selected and placed into 6 groups of 5 animals each. The alloxan-induced diabetic rats were orally supplemented with three doses of P. odoratissimus methanolic seed extracts, 300, 600 and 900 mg/kg bw, or 0.5 mg/kg of glibenclamide for 2 weeks. The glucose, HbA1c, and lipid profile were measured from the blood sample taken from all studied groups. The results were expressed as mean ± SEMs and compared with repeated measurement using SPSS Version 19.0. The methanolic seed extract of P. odoratissimus significantly reduced (p<0.05) the blood glucose level, with a high dose producing 79.15% reduction after 14 days, compared with the control and glibenclamid-treated groups. Furthermore, the seeds extract significantly reduced the concentration of HbA1c, TC, TG and LDL while increasing HDL in alloxan–induced diabetic rats. The P. odoratissimus could be used to effectively manage diabetes and other related complications.