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Anti-Inflammatory and Anti-Oxidative Therapeutic Approach in Chronic Kidney Disease with Statin Consumption

Abstract

Maftuchah Rochmanti, Nadira Muthi Tsania, Sharifa Audi Salsabila, Mochammad Thaha

Inflammation and oxidative stress are 2 factors that play an important role in Chronic Kidney Disease (CKD). Controlling these 2 factors is expected to give better kidney functions outcomes. Statins have anti-inflammatory and antioxidative stress effects apart from their lipid-lowering effect. In this study, we want to analyze that statin might be one of a renoprotective agent through their pleiotropic effect as an anti-inflammation and anti-oxidative in CKD patients. This is a cross-sectional study that enrolled of 40 patients with CKD: 20 patients consumed statin and 20 patients did not consume statin. We compared HDL; inflammatory markers: high sensitive – C reactive protein (hsCRP), absolute neutrophil count, absolute leukocyte count, absolute eosinophil count, and neutrophil-lymphocyte ratio (NLR); and oxidative stress marker malondialdehyde (MDA) with kidney functions (GFR, cystatin c, BUN, albumin urine, and creatinine serum) between groups. Then we analyze the correlation between HDL, inflammatory markers, and oxidative marker with kidney functions. The results are HDL and MDA had a correlation with all the kidney function, hs-CRP correlated with GFR, cystatin c, and BUN, and NLR correlated with GFR, cystatin c, BUN, and creatinine serum. Statin group significantly have lower hs-CRP, NLR, and MDA. HDL, absolute neutrophil, leukocyte, and eosinophil count are lower in the statin group but not significantly. All the kidney function markers significantly have a better outcome in the statin group. This study concludes that lowering inflammation and oxidative stress levels using statin could be one of the strategy therapies in CKD to achieve better kidney function outcomes.

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