APOPTOSIS INDUCING POTENTIAL AND IMMUNOMODULATION OF COLOCASIA ESCULENTA AGAINST MYCOBACTERIAL SPECIES

Abstract

Saeed Arrak Turkey,Mustafa M.Farhan, Essa D Alhtheal, kamal jawad awni.

Colocasia esculenta (C. esculenta) is said to be widely cultivated plant species of Araceae family, used for consumption as food and also used in medicine. of both leaves and tubers. Commonly called as Taro, and contains a vast range of bioactive compounds like flavanoids, terpenoids and alkaloids. Corms of this plant is said to processes pharmacological activities to treat several diseases. The present study is aimed to study the possible immunomodulatory and apoptotic potential of this sample to treat and cure against the
Mycobacteria species. The corms dried and extracted with methanol, hexane, acetone and dichloromethane and used to study the antimycobacterial activity by MIC activity and total activity. Its potent antiinflammatory activity was studied by the cytokine assay targeting the IL-6, TNF and Il-10 and apoptotic inducing potential by Annexin assay. The methanol extract showed maximum MIC values as compared to the positive control rifampicin. In accordance to the above result, methanol extract also showed an inducing apoptotic potential of 73±0.92 at 290μg/ml (Rifampicin 89±2.12). Methanol extract also significantly reduced the IL-6 and TNF levels to 11.23 ± 0.23pg/ml and 9.29± 0.41 respectively at 290μg/ml. It also enhanced the levels of IL-10 from 12.11± 0.71 (0.29μg/ml) to
48.76± 0.81 (290μg/ml); P < 0. 005.The present study confirmed the positive effect of the methanol extract as immunomodulatory and antiinflamatory by showing an inhibition in the expression of IL-6 and TNF. Thus in conclusion C.esculenta could be used as the best antiinflammatory candidate and immunomodulatory supplement due to its containing many bioactive compounds.

Most Viewed Articles
  • Dental Development between Assisted Reproductive Therapy (Art) and Natural Conceived Children: A Comparative Pilot Study Norzaiti Mohd Kenali, Naimah Hasanah Mohd Fathil, Norbasyirah Bohari, Ahmad Faisal Ismail, Roszaman Ramli SRP. 2020; 11(1): 01-06 » doi: 10.5530/srp.2020.1.01
  • Psychometric properties of the World Health Organization Quality of life instrument, short form: Validity in the Vietnamese healthcare context Trung Quang Vo*, Bao Tran Thuy Tran, Ngan Thuy Nguyen, Tram ThiHuyen Nguyen, Thuy Phan Chung Tran SRP. 2020; 11(1): 14-22 » doi: 10.5530/srp.2019.1.3
  • A Review of Pharmacoeconomics: the key to “Healthcare for All” Hasamnis AA, Patil SS, Shaik Imam, Narendiran K SRP. 2019; 10(1): s40-s42 » doi: 10.5530/srp.2019.1s.21
  • Deuterium Depleted Water as an Adjuvant in Treatment of Cancer Anton Syroeshkin, Olga Levitskaya, Elena Uspenskaya, Tatiana Pleteneva, Daria Romaykina, Daria Ermakova SRP. 2019; 10(1): 112-117 » doi: 10.5530/srp.2019.1.19
Most Downloaded
  • Dental Development between Assisted Reproductive Therapy (Art) and Natural Conceived Children: A Comparative Pilot Study Norzaiti Mohd Kenali, Naimah Hasanah Mohd Fathil, Norbasyirah Bohari, Ahmad Faisal Ismail, Roszaman Ramli SRP. 2020; 11(1): 01-06 » doi: 10.5530/srp.2020.1.01
  • Manilkara zapota (L.) Royen Fruit Peel: A Phytochemical and Pharmacological Review Karle Pravin P, Dhawale Shashikant C SRP. 2019; 10(1): 11-14 » doi: 0.5530/srp.2019.1.2
  • Pharmacognostic and Phytopharmacological Overview on Bombax ceiba Pankaj Haribhau Chaudhary, Mukund Ganeshrao Tawar SRP. 2019; 10(1): 20-25 » doi: 10.5530/srp.2019.1.4
  • A Review of Pharmacoeconomics: the key to “Healthcare for All” Hasamnis AA, Patil SS, Shaik Imam, Narendiran K SRP. 2019; 10(1): s40-s42 » doi: 10.5530/srp.2019.1s.21
  • A Prospective Review on Phyto-Pharmacological Aspects of Andrographis paniculata Govindraj Akilandeswari, Arumugam Vijaya Anand, Palanisamy Sampathkumar, Puthamohan Vinayaga Moorthi, Basavaraju Preethi SRP. 2019; 10(1): 15-19 » doi: 10.5530/srp.2019.1.3