Aqueous Extract of Boswellia against Rifampicin Toxicity in rats

Abstract

Amal Umran Mosa, Ban Hoshi khalaf and Salam Ahmed Abed

The aim of this study is to evaluate the rifampicin toxicity in albino rat’s liver and kidney and the reverse effect of boswellia plant extract. The study was conducted on twenty-four albino rats, maintained in animal house in college of pharmacy of Kerbala University in fourteen consequent days. The study was designed to evaluate hepatotoxicity in four albino rats’ groups: control, boswellia plant drenched, parenteral rifampicin and rifampicin and boswellia groups. Biochemical investigations were achieved to evaluate the liver toxicity, by measuring liver enzyme, blood total protein and albumin, urea and creatinine in addition to liver, kidney and lung histopathological study. Biochemical studies show decrease in the hepatic enzymes and renal function tests parameters. This mean it has protective effects against rifampicin toxicity. At the same time, Histopathological observations found that less inflammation and deterioration in the tissues of boswellia treated animals compared with animals fed with rifampicin only. Boswellia can reduce and protect the animal from the renal and hepatic toxicity resulting from rifampicin long used.