Assessing the Fat Mass and Obesity Associated Gene Polymorphisms (rs17817449 and rs1588413) in Obesity and Type 2 Diabetes Mellitus

Abstract

Abdulhussein A. Algenabi, Majid K. Hussein, Najah R. Hadi, Fadhil A. Nasser, Ghizal Fatima, Hayder A. Al-Aubaidy.

This study aims to evaluate the effects of FTO gene polymorphism (rs17817449andrs1588413) as predictor/ risk factors of type 2 diabetes mellitus in obese Iraqi population. Four hundred obese participants clinically diagnosed with type 2 diabetes were enrolled in this study. A similar matching group of obese non-diabetic control group was also included in this study. Multi-nominal logistic regression analysis applied to study genotype and allele frequencies for FTO gene polymorphism (rs17817449, rs1588413) in patients and control groups. The homozygous genotype significantly (OR= 4.61, CI 95% 2.61-8.12, P<0.001) increases the risk of T2DM by approximately two folds with regarding to those of the wild type after adjustment for other factors (age, sex and BMI).As for the FTO gene polymorphism (rs1588413): The homozygous genotype significantly (OR= 10.68, CI 95% 5.04-22.6, P<0.001) increased the risk of T2DM. The FTO gene polymorphisms rs17817449 and rs1588413are strong predictors for the development of type 2 diabetes mellitus in obese patients.