Assessment of Risk Factors Associated with Anaemia Severity among Breast Cancer Patients Undergoing Chemotherapy in Malaysia

Abstract

Fares M.S Muthanna, Mahmathi Karuppannan, Bassam Abdul Rasool Hassan, Ali Haider Mohammed

Objectives: The purpose of this study was to determine the association between anaemia severity and risk factors among breast cancer patients.
Methods: A prospective study design was conducted in three different oncology centres in Malaysia where 120 anaemic breast cancer patients (haemoglobin < 12 g/dL) were identified through medical chart review. Patients were followed-up for three cycles of chemotherapy and data such as haemoglobin (Hb) levels and demographic or clinical data were also recorded on each follow-up. Data were analysed using SPSS.
Results: The average mean of Hb level of all follow-ups was 10.34 ± 0.73 g/dL. A chi-square and multiple logistic regression analysis revealed a significant strong association between anaemia severity and associated risk factors, i.e., demographic data (age, body mass index [BMI], and marital status), chemotherapy data (dose delay, number of regimens, and type of chemotherapy), and cancer stage.
Conclusion: Factors that have a great impact on anaemia severity were identified in which oncologist and healthcare professionals can take them into consideration to reduce the negative effect of anaemia on patients’ health care. Besides, results of such studies could significantly help in developing effective treatment guidelines for this crucial medical issue.