Assessment of Some Biomarkers Related with Recurrent Miscarriages in Iraq

Abstract

Yahaya M. Jabber, Alaa Jawad Hassan, Hussein N. Abdullah.

The present study was aimed to determine some of the major biomarkers among women patients with a history of recurrent miscarriages that associate with antiphospholipid syndrome (APS), in addition, to know the positive prevalence of antiphospholipid (IgG) antibodies. The study enrolled 88 participants, including 55 aborted women with a history of recurrent miscarriages (RM) in the first trimester of pregnancy, and 33 apparently healthy subjects were selected as a control group who attend the maternity and pediatrics hospital in Babylon governorate, where their ages ranged between 18 - 35 year. Sera from all participants were tested to an assessment of some parameters related to this study. It was observed that a high positive prevalence of anticardiolipin (aCL) IgG in patients which 62.5% compared with 60.2% and 52.3% for antiphospholipid autoantibodies (aPL) IgG and anti β2-glycoprotein I (aβ2GPI) IgG respectively, also the lower ratio was 26.1% for Lupus anticoagulant (LA) IgG at a level of statistical significance less than 0.05. The data demonstrated that elevate of odds ratio (OR) to aPL IgG which reached 59.21%, while for aCL IgG, aβ2GPI IgG, and LA IgG which 25.47%, 16.40 %, and 9.57 % respectively. The statistical results revealed that significant difference in the mean concentration of factor V Leiden (FVL) in aborted women (28.78 ± 3.62 ng/ml) when compared with apparently healthy subjects (19.66±3.22 ng/ml). The concentration of tumor necrosis factor- alpha (TNF-α) in women with recurrent miscarriages was 78.50±6.61 pg/ml, but it 959.50±6.35 pg/ml in the control group. In addition, the level of 25 (OH) vitamin D in patients and control groups were 37.45 ± 3.92 ng/ml and 35.96 ± 3.77 ng/ml respectively with no significant differences (P = 0.082). The ROC curve was used to evaluate the prevalence of IgG for variables of APS, where the degree of accuracy ranged from good to excellent for all IgG of variables depending on the area under curve (AUC). In addition, the sensitivity of aPL IgG was higher that reached 100 %(95% CI 93.5 - 100.0), but for aβ2GPI IgG and IgG aCL were reached 92.73% (95% CI 82.4-98.0) and 87.27% (95% CI 75.5-94.7) consecutively, as well as, it was 83.64%(95% CI 71.2-92.2) for LA IgG.

 

How to Cite this Article
Pubmed Style

Jabber YM, Hassan AJ, Abdullah HN. Assessment of Some Biomarkers Related with Recurrent Miscarriages in Iraq. SRP. 2020; 11(9): 156-162. 
doi:10.31838/srp.2020.9.27

Web Style

Jabber YM, Hassan AJ, Abdullah HN. Assessment of Some Biomarkers Related with Recurrent Miscarriages in Iraq. http://www.sysrevpharm.org/?mno=2892 [Access: March 29, 2021]. doi:10.31838/srp.2020.9.27

AMA (American Medical Association) Style

Jabber YM, Hassan AJ, Abdullah HN. Assessment of Some Biomarkers Related with Recurrent Miscarriages in Iraq. SRP. 2020; 11(9): 156-162. doi:10.31838/srp.2020.9.27



Vancouver/ICMJE Style

Jabber YM, Hassan AJ, Abdullah HN. Assessment of Some Biomarkers Related with Recurrent Miscarriages in Iraq. SRP. (2020), [cited March 29, 2021]; 11(9): 156-162. doi:10.31838/srp.2020.9.27



Harvard Style

Jabber, Y. M., Hassan, . A. J. & Abdullah, . H. N. (2020) Assessment of Some Biomarkers Related with Recurrent Miscarriages in Iraq. SRP, 11 (9), 156-162. doi:10.31838/srp.2020.9.27



Turabian Style

Jabber, Yahaya M., Alaa Jawad Hassan, and Hussein N. Abdullah. 2020. Assessment of Some Biomarkers Related with Recurrent Miscarriages in Iraq. Systematic Reviews in Pharmacy, 11 (9), 156-162. doi:10.31838/srp.2020.9.27



Chicago Style

Jabber, Yahaya M., Alaa Jawad Hassan, and Hussein N. Abdullah. "Assessment of Some Biomarkers Related with Recurrent Miscarriages in Iraq." Systematic Reviews in Pharmacy 11 (2020), 156-162. doi:10.31838/srp.2020.9.27



MLA (The Modern Language Association) Style

Jabber, Yahaya M., Alaa Jawad Hassan, and Hussein N. Abdullah. "Assessment of Some Biomarkers Related with Recurrent Miscarriages in Iraq." Systematic Reviews in Pharmacy 11.9 (2020), 156-162. Print. doi:10.31838/srp.2020.9.27



APA (American Psychological Association) Style

Jabber, Y. M., Hassan, . A. J. & Abdullah, . H. N. (2020) Assessment of Some Biomarkers Related with Recurrent Miscarriages in Iraq. Systematic Reviews in Pharmacy, 11 (9), 156-162. doi:10.31838/srp.2020.9.27

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