Assessment Serum Levels of Neopterin, IL-6, IL-1?, hs-CRP, TNF-? and MMP 9 in Iraqi Rheumatoid Arthritis Patients

Abstract

Shakir .F. T. Alaaraji, Mjid A. Mohisen, Muthanna M. Awad

Background
Rheumatoid arthritis (RA) is a sore public prolonged arthropathy of indefinite etiology.
Objective
To explore the sera concentrations of neopterin (NPT), interleukin-6 (IL-6), interleukin-1β (IL-1β), tumor necrosis factor alpha (TNF-α), high sensitivity C-reactive protein (hs-CRP) and matrix metalloproteinase-9 (MMP-9) in RA patients.
Methods
The work involved 40 RA Iraqi patients and 40 healthy control (HC) matched by age and sex. Sera concentrations of neopterin, TNF- α, IL-1β, IL-6, MMP-9 and hs-CRP were estimated by commercially available ELISA kit.
Results
Sera concentrations of neopterin, IL-1β, IL-6, MMP-9, TNF-α and hs-CRP were importantly greater (P<0.001) in RA cases than HCs. There was an important positive link between TNF-α and IL-1β.
Conclusion
These data establish that RA cases have great concentrations of inflammatory indicators, and these values are linked with the neopterin. Current results submit a potential function of these indicators in RA pathogenesis. Furthermore, these parameters can be served as signs of illness action in the identification and therapy of RA.