Assessment the Estrogenic Efficacy of L-carnitine on Female Rats treated with Sodium Fluoride

Abstract

Zinah Mohammed Al_Shammari, Zahraa Zuhair Alsaidi

This investigation has been carried out for determine the estrogenic activity of L-carnitine, and role in female reproductive system in sodium fluoride treated rats. Mature forty female rats were isolated randomly to 4 groups while were taken care every day as follow of 30 days; group T1 control were administered tap water ;group T2 administered sodium fluoride in tap water 100 ppm; group T3were intubated daily L-carnitine 100mg/kg B.W; group T4 were intubated daily L-carnitine 100mg/kg B.W and administered sodium fluoride in tap water 100 ppm. Blood samples were obtained at end of experiments for estimation of serum estrogen, progesterone ,FSH, LH concentrations. Samples from both organs were also obtained for histo-physiological study (estimation ovarian & uterine weights, diameter the graafian follicles and percentage intact and atretic graafian follicles also thickness of the uterine wall layers). A significant decrease in serum estrogen,progesterone, FSH, LH concentration, also, the ovarian and uteri weights in group T2, as well as, statistical analysis and examination of histological sections revealed a significant decrease in the diameter and percentage of intact graafian follicles , also thickness of the uterine wall layers and increase in percentage of atretic graafian follicles. Whereas, The results pointed the beneficial effects of LC to improvement the previous parameters, against NaF (T4), through a significant increase in hormonal profile concentration and the ovarian and uteri weights same results were also recorded in the thickness of all uterine layers (endometrium, myometrium and stroma) parallel with alleviating the toxicity induced by NaF.