Association between Interleukin-23 Receptor Polymorphism and Asthma

Abstract

Anfal A. K. AL-Bazoon, Thanaa M. Jouda, Ahmed H. Jasim

“Asthma”: A public health problem mainly effects lung ,the main character is inflammation the lead to narrowing of the bronchi creating difficulty breathing ,its multifactorial disorder and genetic predisposing one of the etiological and risk factor .one of the genetic study is focusing on signaling through” IL23 receptor (IL23R)”. IL-23R is important for signaling of IL-23. Which considered an important role in immune-regulatory pathway. The present study aims to evaluate IL-23R gene polymorphism and its role to increases or decreases tendency to asthma. In this case-control study fifty patients with asthma compared with control group, fifty seemingly healthy the diagnosis made in by specialist consultation at Marjan Medical Hospital in Hilla, Iraq. Analysis of data revealed there are substantial difference in frequency of IL-23 R (rs11209026) G>A polymorphism between asthmatic patients and controls ,opposite to this result ,the another polymorphism (rs1884444) in the same receptor proofed no substantial difference (between) asthmatic patients and (controls) .The results of the work concluded, that patients with GG allele for IL-23 R (rs11209026) have increased susceptibility to asthma compared with GA allel. Also, the present study suggests that IL-23R (rs1884444) is not considered risk factor for asthma.