Association of PTEN (rs/1234213 rs/1234220) Gene Polymorphisms with Liver Cancer Risk in Iraqi Patients

Abstract

Reem K. Ibrahim.

Phosphatase and tensin homolog (PTEN) is a protein that doing on the cancer suppressor by dephosphorylating the lipid second messenger phosphatidylinositol 3,4,5-trisphosphate that supervision a different of biological path way including cell proliferation, migration, and death [1].
The motive of this find out about to decide the relationships between the polymorphism of PTEN gene and threat of liver cancer by way of use single-tube method that collects the tetra-primer ARMS PCR experiment, SYBR inexperienced –with Real-time PCR, and melting point check with particular primer to locate the single nucleotide polymorphisms (SNP) of the gene. A pattern used to be performed= (65n) samples included 15 controls and 50 sufferers from Iraqi patient.
It was observed that PTEN (rs/1234213 rs/1234220,) gene have three genotypes .It was also noticed that The three genotype (GG, GA and AA) of PTEN rs1234213 and CC, TT genotype of PTEN rs1234220 may lead to decrease the risk of infection (OR=0.261, 0.261 and 0.00) (0.261 and 0.784) in Respectively.at the same time was discovered a statistical significance between CT and TT polymorphisms of PTEN rs1234220 with risk of liver cancer. The study also showed that the number of allele G of PTEN rs1234213 is higher than the allele A for both groups, while the genotype of PTEN rs1234220 was showed that the allele T is highest percentage in control and patient group from allele C.