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CDDO Me Provides Kidney Protective Impacts against Ischemia/Reperfusion Injury via Inhibition of Oxidative Stress and Inflammation by Targeting Nrf2 and NF-kB Signaling Pathways

Abstract

NAJAH R. HADI, FADHIL AL-AMRAN, THU-ALFEQAR R. TWEIJ, MOHAMMED E. MANSUR

Ischemia reperfusion injury (IRI) is a causative factor of organ failure as in renal ischemia which is associated with increasing of mortality rate. It is a popular pathological condition mainly accompanied with an aggravation of tissue injury. Oxidative stress and Inflammation participate in the pathophysiology of renal IRI. This is by increasing the production of reactive oxygen species, pro-inflammatory cytokines and chemokine and other immune mediators which intensify the kidney damage. Previous studies have demonstrated that CDDO Me has cytoprotective, antioxidant, anti-inflammatory, and immunomodulating properties. This study aims to investigate the renoprotective impacts of CDDO Me (Bardoxolone methyl) in rat model IRI by targeting of Nrf2, NF-kB signaling pathway. Rats in control and vehicle groups demonstrated significant elevation in BUN, Scr, NGAL, F2-isoprostane. Furthermore, activated NF-kB, and Nrf2 pathways, and HO-1 was increased. Kidneys of pretreated rats with CDDO Me showed histological and functional amelioration as evidenced by significant reduction in BUN, Scr and NGAL, significant reduction in F2- isoprostane. Moreover, it was found that Nrf2 pathway was significantly more activated and HO-1 more expressed in renal tissue when compared with control and vehicle groups. The antiinflammatory effects of CDDO Me appeared clearly through the significant inhibition of NF-kB pathway. CDDO me alleviated the kidney damage that induced by bilateral renal IR, and this protective impacts may be done by activating the Nrf2 and rising its downstreamHO-1 and inhibition of NF-kB pathway.

How to Cite this Article
Pubmed Style

NAJAH R. HADI, FADHIL AL-AMRAN, THU-ALFEQAR R. TWEIJ, MOHAMMED E. MANSUR. CDDO Me Provides Kidney Protective Impacts against Ischemia/Reperfusion Injury via Inhibition of Oxidative Stress and Inflammation by Targeting Nrf2 and NF-kB Signaling Pathways. SRP. 2020; 11(1): 108-118. doi:10.5530/srp.2020.1.16

Web Style

NAJAH R. HADI, FADHIL AL-AMRAN, THU-ALFEQAR R. TWEIJ, MOHAMMED E. MANSUR. CDDO Me Provides Kidney Protective Impacts against Ischemia/Reperfusion Injury via Inhibition of Oxidative Stress and Inflammation by Targeting Nrf2 and NF-kB Signaling Pathways. http://www.sysrevpharm.org/?mno=82748 [Access: March 29, 2021]. doi:10.5530/srp.2020.1.16

AMA (American Medical Association) Style

NAJAH R. HADI, FADHIL AL-AMRAN, THU-ALFEQAR R. TWEIJ, MOHAMMED E. MANSUR. CDDO Me Provides Kidney Protective Impacts against Ischemia/Reperfusion Injury via Inhibition of Oxidative Stress and Inflammation by Targeting Nrf2 and NF-kB Signaling Pathways. SRP. 2020; 11(1): 108-118. doi:10.5530/srp.2020.1.16


Vancouver/ICMJE Style

NAJAH R. HADI, FADHIL AL-AMRAN, THU-ALFEQAR R. TWEIJ, MOHAMMED E. MANSUR. CDDO Me Provides Kidney Protective Impacts against Ischemia/Reperfusion Injury via Inhibition of Oxidative Stress and Inflammation by Targeting Nrf2 and NF-kB Signaling Pathways. SRP. (2020), [cited March 29, 2021]; 11(1): 108-118. doi:10.5530/srp.2020.1.16


Harvard Style

NAJAH R. HADI, FADHIL AL-AMRAN, THU-ALFEQAR R. TWEIJ, MOHAMMED E. MANSUR (2020) CDDO Me Provides Kidney Protective Impacts against Ischemia/Reperfusion Injury via Inhibition of Oxidative Stress and Inflammation by Targeting Nrf2 and NF-kB Signaling Pathways. SRP, 11 (1), 108-118. doi:10.5530/srp.2020.1.16


Turabian Style

NAJAH R. HADI, FADHIL AL-AMRAN, THU-ALFEQAR R. TWEIJ, MOHAMMED E. MANSUR. 2020. CDDO Me Provides Kidney Protective Impacts against Ischemia/Reperfusion Injury via Inhibition of Oxidative Stress and Inflammation by Targeting Nrf2 and NF-kB Signaling Pathways. Systematic Reviews in Pharmacy, 11 (1), 108-118. doi:10.5530/srp.2020.1.16


Chicago Style

NAJAH R. HADI, FADHIL AL-AMRAN, THU-ALFEQAR R. TWEIJ, MOHAMMED E. MANSUR. "CDDO Me Provides Kidney Protective Impacts against Ischemia/Reperfusion Injury via Inhibition of Oxidative Stress and Inflammation by Targeting Nrf2 and NF-kB Signaling Pathways." Systematic Reviews in Pharmacy 11 (2020), 108-118. doi:10.5530/srp.2020.1.16


MLA (The Modern Language Association) Style

NAJAH R. HADI, FADHIL AL-AMRAN, THU-ALFEQAR R. TWEIJ, MOHAMMED E. MANSUR. "CDDO Me Provides Kidney Protective Impacts against Ischemia/Reperfusion Injury via Inhibition of Oxidative Stress and Inflammation by Targeting Nrf2 and NF-kB Signaling Pathways." Systematic Reviews in Pharmacy 11.1 (2020), 108-118. Print. doi:10.5530/srp.2020.1.16


APA (American Psychological Association) Style

NAJAH R. HADI, FADHIL AL-AMRAN, THU-ALFEQAR R. TWEIJ, MOHAMMED E. MANSUR (2020) CDDO Me Provides Kidney Protective Impacts against Ischemia/Reperfusion Injury via Inhibition of Oxidative Stress and Inflammation by Targeting Nrf2 and NF-kB Signaling Pathways. Systematic Reviews in Pharmacy, 11 (1), 108-118. doi:10.5530/srp.2020.1.16

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