Chlorella Vulgaris Extract Cream as A Formulation of Bone Remodelling

Abstract

Edy Machmud, Nina Permatasari

Chlorella vulgaris is one of the green microalgae that has many contents that are beneficial to humans. The bioactive component of microalgae has antimicrobial, antitumor, antioxidant, antiviral, antifungal, and anti-inflammatory activities. Moreover, these bioactive components can produce collagen, a protein that will support cell regeneration, for example, in bone remodeling. One way to increase the effectiveness of using C. vulgaris in the bone remodeling process is to formulate C. vulgaris extract in cream form. The cream is a semi-solid preparation in the form of an emulsion containing one or more drug ingredients dissolved or dispersed in a suitable base material and contains no less than 60% water. The purpose of this study was to determine the exact formulation of C. vulgaris cream extract and to measure the effect of C. vulgaris cream extract on the oral mucosa of test animals. Our research is implementing organoleptic, homogeneity, spreadability, viscosity, pH, viscosity, flow type, centrifugation, and irritation tests. The results demonstrated that cream with a concentration of 15% was better than other levels. Cream of 5%, 10%, and 15% concentration did not irritate the mucosa of the test animals. We concluded that the cream with the range concentration did not provoke any oral mucosa adverse reaction of the test animals based.