Clinical Profile Of A Group Of Iraqi Children With Transplanted Liver

Abstract

Rabab Farhan Thejeal.

Back ground: Iraq is a developing country with limited medical resources, especially those services related to organ transplant, particularly liver transplant. With high incidence of consanguineous marriages leading to inherited diseases of liver and many metabolic diseases with liver involvement. Aim of study: To highlight the liver transplant outcome in a sample of Iraqi children. Methods: Since 2011 ministry of health started assessing children in need for liver transplant as the last resort for survival, sending them abroad to highly specialized liver transplant centers in India and Turkey. Twenty-two patients who had underwent living donor’s liver transplant from May of 2011 till May of 2019 were included. The patient’s data records were evaluated retrospectively. The
medical profile and outcome of patients and overall survival was analyzed. Results: All transplanted livers were from living relative donors, mothers in 63.6% children, while father’s donation in 36.4% children, the mean age at time of transplant was (4.23±3.2 years), males were 1722 (77.3%) while females were 522 (22.7%). Mean pediatric end stage liver diseases (PELD) score before the operation was 18.64-+6.7. The indication for liver transplant were progressive familial intrahepatic cholestasis in 8 22 (36.4%) children, followed by biliary atresia 622 (27%), Complications following transplant operation included rejections in 8 children (5 acute 22.7%, 3 chronic 13.6%), followed by 4 hematological (18%), 2 (9%) biliary complications, 2 (9 %) dermatological and 2 nephrological and 2 right sided diaphragmatic hernia, while malignancy, hepatic collection and chronic diarrhea occur in one child. One-year Overall survival rate was 100%, 3- and 5-years overall survival was 90 %. Conclusion: Liver transplant in children has of very rewarding outcome with 90% five years overall survival rate with significant growth and physical improvement.