Abstract

Yasin H. Majeed

Background: Celiac disease (CD) is a public hereditary, autoimmune &multifactorial gastro-intestinal disorder in children and adults defined as a permanent gluten-sensitive Enteropathy. There is no previous study on Socio-demographic, clinical, endoscopic, and histological features of celiac disease in the AL-Ramadi district (west of Iraq) patients.
Objective: To identify the clinical, endoscopic, and histological features of celiac disease at Al-Ramadi district (west of Iraq) to reach the accurate CD diagnosis.
Patients and Methods:161 consecutive new CD cases diagnosed in the Gastroenterology Clinic of AL-Ramadi teaching hospital between August 2017 and March 2020 were included in a retrospective cross-sectional study, of them, 85 females were females76 males. The clinical features and endoscopic findings were recorded for each CD patient. In all cases, gastro-intestinal biopsies with serum ''anti-tissue transglutaminase' (Anti¬tTG) had been determined & tested for the CD diagnosis. Histopathology results had been divided using modified Marsh taxonomy.
Results: The mean age of celiac disease patients was 24.16 ± 14.751. There was a non- statistically significant differences between the genders in studied countries (p = 0.478). Abdominal pain, Bloating, Diarrhea, vomiting, altered bowel habit, Pallor, short stature and Constipation were the most common finding of CD patients with the following percent (23.6%), (23.0%), (14.3%),7.5%,6.2%,5.0%,5.0% respectively. The CD investigations shows were: (a) IDA in 105 (65.2%) patients; (b) low ferritin in 17 (10.6%) patients; (c) elevated SGPT 3 (1.9%) patients; (d) pancytopenia and 1 (0. 6%) patients. IgA anti-tTG <10iu/ml 6.2%, IgA between 10.1-20 iu /ml 82.0% while IgA anti tTG>20iu/ml in 11.8%. A statistical correlation was found between endoscopical and histopathological findings of celiac disease (p = 0.0001), and this correlation was more prominent in the scalloping aspect of duodenal mucosa. A statistical correlation was found between Anti- tTG IgA iu /ml levels and histopathological findings of celiac disease (p = 0.0002).
Conclusion: Histopathological findings correlate both with the endoscopic finding and the IgA TTGA levels of celiac disease patients. Furthermore, half of the CD patients with Iron deficiency anemia.

 

How to Cite this Article

Pubmed Style Yasin H. Majeed. Clinical, Serological and Histopathological Aspect of Celiac Disease at AL-Ramadi Province West of Iraq. SRP. 2021; 12(1): 435-439. doi:10.31838/srp.2021.1.64 Web Style Yasin H. Majeed. Clinical, Serological and Histopathological Aspect of Celiac Disease at AL-Ramadi Province West of Iraq. http://www.sysrevpharm.org/?mno=36845 [Access: March 30, 2021]. doi:10.31838/srp.2021.1.64 AMA (American Medical Association) Style Yasin H. Majeed. Clinical, Serological and Histopathological Aspect of Celiac Disease at AL-Ramadi Province West of Iraq. SRP. 2021; 12(1): 435-439. doi:10.31838/srp.2021.1.64 Vancouver/ICMJE Style Yasin H. Majeed. Clinical, Serological and Histopathological Aspect of Celiac Disease at AL-Ramadi Province West of Iraq. SRP. (2021), [cited March 30, 2021]; 12(1): 435-439. doi:10.31838/srp.2021.1.64 Harvard Style Yasin H. Majeed (2021) Clinical, Serological and Histopathological Aspect of Celiac Disease at AL-Ramadi Province West of Iraq. SRP, 12 (1), 435-439. doi:10.31838/srp.2021.1.64 Turabian Style Yasin H. Majeed. 2021. Clinical, Serological and Histopathological Aspect of Celiac Disease at AL-Ramadi Province West of Iraq. Systematic Reviews in Pharmacy, 12 (1), 435-439. doi:10.31838/srp.2021.1.64 Chicago Style Yasin H. Majeed. "Clinical, Serological and Histopathological Aspect of Celiac Disease at AL-Ramadi Province West of Iraq." Systematic Reviews in Pharmacy 12 (2021), 435-439. doi:10.31838/srp.2021.1.64 MLA (The Modern Language Association) Style Yasin H. Majeed. "Clinical, Serological and Histopathological Aspect of Celiac Disease at AL-Ramadi Province West of Iraq." Systematic Reviews in Pharmacy 12.1 (2021), 435-439. Print. doi:10.31838/srp.2021.1.64 APA (American Psychological Association) Style Yasin H. Majeed (2021) Clinical, Serological and Histopathological Aspect of Celiac Disease at AL-Ramadi Province West of Iraq. Systematic Reviews in Pharmacy, 12 (1), 435-439. doi:10.31838/srp.2021.1.64