Coltsfoot Leaves (Tussilago farfara L.) ? A Promising Source of Essential Amino Acids
Abstract
Chromchenkova E.P., Bokov D.O., Bessonov V.V., Samylina I.A., Kakhramanova S.D., Chevidaev V.V., Sokhin D.M., Balobanova N.P., Evgrafov A.A., Krasnyuk I.I.(junior), Kudashkina N.V., Galiakhmetova E.K., Marakhova A.I., Moiseev D.V
Objective: Free and bounded amino acids are one of the valuable biologically active substances (BAS) containing in medicinal plants with other BAS groups. The research aims to determine the profile and content of free and bounded amino acids in coltsfoot leaves infusion by HPLC-UV, as well as suggest alternative ways to use it in medicine.
Materials and methods: Coltsfoot leaves (crushed herbal drug) were used as plant material for preparing infusion and analysis. Amino acids profile and content were analyzed by RP-HPLC-UV after pre-column derivatization with o-phthalaldehyde and 3-mercaptopropionic acid (OPA) (derivatization of primary amines) and with fluorenylmethyloxycarbonyl (FMOC) (secondary amines). The sources of scientific literature concerning the amino acid composition of crushed herbal drugs were also studied.
Results: 10 free and 13 bounded amino acids were identified in coltsfoot leaves infusion. Total content was 44.04±2.20 mg/g (Arg > Tyr > Gln > Ala > Asn > Met > Ile > Val > Lys > Leu) and 57.79±2.89 mg/g (Arg > Gln > Lys > Tyr > Gly > Asn > Val > Thr > Ala > Ile > Nva > Leu > Met) respectively. Content of essential amino acids – 0,89±0,04 mg/g (5 free); 9,58±0,48 mg/g (5 bounded).
Conclusions: Since the coltsfoot leaves contain a significant amount of arginine, studies involving the prevention and adjunctive treatment of viral diseases, including SARS-CoV-2 virus infection (COVID-19), are promising.
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| Pubmed Style Chromchenkova E.P., Bokov D.O., Bessonov V.V., Samylina I.A., Kakhramanova S.D., Chevidaev V.V., Sokhin D.M., Balobanova N.P., Evgrafov A.A., Krasnyuk I.I.(junior), Kudashkina N.V., Galiakhmetova E.K., Marakhova A.I., Moiseev D.V.. Coltsfoot Leaves (Tussilago farfara L.) – A Promising Source of Essential Amino Acids. SRP. 2020; 11(6): 221-225. doi:10.31838/srp.2020.6.34 Web Style Chromchenkova E.P., Bokov D.O., Bessonov V.V., Samylina I.A., Kakhramanova S.D., Chevidaev V.V., Sokhin D.M., Balobanova N.P., Evgrafov A.A., Krasnyuk I.I.(junior), Kudashkina N.V., Galiakhmetova E.K., Marakhova A.I., Moiseev D.V.. Coltsfoot Leaves (Tussilago farfara L.) – A Promising Source of Essential Amino Acids. http://www.sysrevpharm.org/?mno=112869 [Access: March 29, 2021]. doi:10.31838/srp.2020.6.34 AMA (American Medical Association) Style Chromchenkova E.P., Bokov D.O., Bessonov V.V., Samylina I.A., Kakhramanova S.D., Chevidaev V.V., Sokhin D.M., Balobanova N.P., Evgrafov A.A., Krasnyuk I.I.(junior), Kudashkina N.V., Galiakhmetova E.K., Marakhova A.I., Moiseev D.V.. Coltsfoot Leaves (Tussilago farfara L.) – A Promising Source of Essential Amino Acids. SRP. 2020; 11(6): 221-225. doi:10.31838/srp.2020.6.34 Vancouver/ICMJE Style Chromchenkova E.P., Bokov D.O., Bessonov V.V., Samylina I.A., Kakhramanova S.D., Chevidaev V.V., Sokhin D.M., Balobanova N.P., Evgrafov A.A., Krasnyuk I.I.(junior), Kudashkina N.V., Galiakhmetova E.K., Marakhova A.I., Moiseev D.V.. Coltsfoot Leaves (Tussilago farfara L.) – A Promising Source of Essential Amino Acids. SRP. (2020), [cited March 29, 2021]; 11(6): 221-225. doi:10.31838/srp.2020.6.34 Harvard Style Chromchenkova E.P., Bokov D.O., Bessonov V.V., Samylina I.A., Kakhramanova S.D., Chevidaev V.V., Sokhin D.M., Balobanova N.P., Evgrafov A.A., Krasnyuk I.I.(junior), Kudashkina N.V., Galiakhmetova E.K., Marakhova A.I., Moiseev D.V. (2020) Coltsfoot Leaves (Tussilago farfara L.) – A Promising Source of Essential Amino Acids. SRP, 11 (6), 221-225. doi:10.31838/srp.2020.6.34 Turabian Style Chromchenkova E.P., Bokov D.O., Bessonov V.V., Samylina I.A., Kakhramanova S.D., Chevidaev V.V., Sokhin D.M., Balobanova N.P., Evgrafov A.A., Krasnyuk I.I.(junior), Kudashkina N.V., Galiakhmetova E.K., Marakhova A.I., Moiseev D.V.. 2020. Coltsfoot Leaves (Tussilago farfara L.) – A Promising Source of Essential Amino Acids. Systematic Reviews in Pharmacy, 11 (6), 221-225. doi:10.31838/srp.2020.6.34 Chicago Style Chromchenkova E.P., Bokov D.O., Bessonov V.V., Samylina I.A., Kakhramanova S.D., Chevidaev V.V., Sokhin D.M., Balobanova N.P., Evgrafov A.A., Krasnyuk I.I.(junior), Kudashkina N.V., Galiakhmetova E.K., Marakhova A.I., Moiseev D.V.. "Coltsfoot Leaves (Tussilago farfara L.) – A Promising Source of Essential Amino Acids." Systematic Reviews in Pharmacy 11 (2020), 221-225. doi:10.31838/srp.2020.6.34 MLA (The Modern Language Association) Style Chromchenkova E.P., Bokov D.O., Bessonov V.V., Samylina I.A., Kakhramanova S.D., Chevidaev V.V., Sokhin D.M., Balobanova N.P., Evgrafov A.A., Krasnyuk I.I.(junior), Kudashkina N.V., Galiakhmetova E.K., Marakhova A.I., Moiseev D.V.. "Coltsfoot Leaves (Tussilago farfara L.) – A Promising Source of Essential Amino Acids." Systematic Reviews in Pharmacy 11.6 (2020), 221-225. Print. doi:10.31838/srp.2020.6.34 APA (American Psychological Association) Style Chromchenkova E.P., Bokov D.O., Bessonov V.V., Samylina I.A., Kakhramanova S.D., Chevidaev V.V., Sokhin D.M., Balobanova N.P., Evgrafov A.A., Krasnyuk I.I.(junior), Kudashkina N.V., Galiakhmetova E.K., Marakhova A.I., Moiseev D.V. (2020) Coltsfoot Leaves (Tussilago farfara L.) – A Promising Source of Essential Amino Acids. Systematic Reviews in Pharmacy, 11 (6), 221-225. doi:10.31838/srp.2020.6.34 |
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