Combined Fractional Erbuim-YAG Laser With Botulinum Toxin-A Versus Botulinum Toxin-A Alone For The Treatment Of Hypertrophic Scars And Keloids
Abstract
Seif -Allah Mohamed Elfiky, Hisham Shokeir, Mahmoud S Elbasiouny, Nevien Samy.
Background:
The treatment of hypertrophic scars (HTS) and keloids remains a challenge. Not all treatment modalities have been adequately tested.
Objectives:
We aimed to compare the efficacy between combined fractional Er:YAG with intra-lesional botulinum toxin (Botox) and intra-lesional Botox as a monotherapy for the treatment of HTS and keloids.
Patients and methods:
Thirty patients with HTS and keloids were treated by intra-lesional injection of Botulinum Toxin Type –A (Botox) as a monotherapy and Botox combined with ablative fractional Er:YAG laser. Each lesion was divided into two parts. The allocation of treatment method was randomly selected. One part was treated with Botox intra-lesionally 5 IU/cm2. The other part was subjected to combined intra-lesional Botox and ablative fractional Er:YAG laser (2,940 nm) sessions (4 sessions every 4 weeks). Evaluation of the treatment outcomes was done by the Vancouver Scar Scale (VSS), clinical imaging, and immuno-histochemical studies.
Results:
There was a significant decline in VSS after treatment with the combined regimen compared to the sites treated with botox injection only (P<0.001). Additionally, there was a highly significant difference between the combined treated sides and the Botox monotherapy sides in both the epidermal thickness (P=0.001) and area% hypodermis (P=0.001).
Conclusion:
Treatment of HTS and keloids with the combined approach of Er:YAG and Botox is more effective than Botox alone
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| Pubmed Style Seif -Allah Mohamed Elfiky, Hisham Shokeir, Mahmoud S Elbasiouny, Nevien Samy. Combined Fractional Erbuim-YAG Laser With Botulinum Toxin-A Versus Botulinum Toxin-A Alone For The Treatment Of Hypertrophic Scars And Keloids. SRP. 2021; 12(3): 115-120. doi:10.31838/srp.2021.3.20 Web Style Seif -Allah Mohamed Elfiky, Hisham Shokeir, Mahmoud S Elbasiouny, Nevien Samy. Combined Fractional Erbuim-YAG Laser With Botulinum Toxin-A Versus Botulinum Toxin-A Alone For The Treatment Of Hypertrophic Scars And Keloids. http://www.sysrevpharm.org/?mno=51606 [Access: March 30, 2021]. doi:10.31838/srp.2021.3.20 AMA (American Medical Association) Style Seif -Allah Mohamed Elfiky, Hisham Shokeir, Mahmoud S Elbasiouny, Nevien Samy. Combined Fractional Erbuim-YAG Laser With Botulinum Toxin-A Versus Botulinum Toxin-A Alone For The Treatment Of Hypertrophic Scars And Keloids. SRP. 2021; 12(3): 115-120. doi:10.31838/srp.2021.3.20 Vancouver/ICMJE Style Seif -Allah Mohamed Elfiky, Hisham Shokeir, Mahmoud S Elbasiouny, Nevien Samy. Combined Fractional Erbuim-YAG Laser With Botulinum Toxin-A Versus Botulinum Toxin-A Alone For The Treatment Of Hypertrophic Scars And Keloids. SRP. (2021), [cited March 30, 2021]; 12(3): 115-120. doi:10.31838/srp.2021.3.20 Harvard Style Seif -Allah Mohamed Elfiky, Hisham Shokeir, Mahmoud S Elbasiouny, Nevien Samy (2021) Combined Fractional Erbuim-YAG Laser With Botulinum Toxin-A Versus Botulinum Toxin-A Alone For The Treatment Of Hypertrophic Scars And Keloids. SRP, 12 (3), 115-120. doi:10.31838/srp.2021.3.20 Turabian Style Seif -Allah Mohamed Elfiky, Hisham Shokeir, Mahmoud S Elbasiouny, Nevien Samy. 2021. Combined Fractional Erbuim-YAG Laser With Botulinum Toxin-A Versus Botulinum Toxin-A Alone For The Treatment Of Hypertrophic Scars And Keloids. Systematic Reviews in Pharmacy, 12 (3), 115-120. doi:10.31838/srp.2021.3.20 Chicago Style Seif -Allah Mohamed Elfiky, Hisham Shokeir, Mahmoud S Elbasiouny, Nevien Samy. "Combined Fractional Erbuim-YAG Laser With Botulinum Toxin-A Versus Botulinum Toxin-A Alone For The Treatment Of Hypertrophic Scars And Keloids." Systematic Reviews in Pharmacy 12 (2021), 115-120. doi:10.31838/srp.2021.3.20 MLA (The Modern Language Association) Style Seif -Allah Mohamed Elfiky, Hisham Shokeir, Mahmoud S Elbasiouny, Nevien Samy. "Combined Fractional Erbuim-YAG Laser With Botulinum Toxin-A Versus Botulinum Toxin-A Alone For The Treatment Of Hypertrophic Scars And Keloids." Systematic Reviews in Pharmacy 12.3 (2021), 115-120. Print. doi:10.31838/srp.2021.3.20 APA (American Psychological Association) Style Seif -Allah Mohamed Elfiky, Hisham Shokeir, Mahmoud S Elbasiouny, Nevien Samy (2021) Combined Fractional Erbuim-YAG Laser With Botulinum Toxin-A Versus Botulinum Toxin-A Alone For The Treatment Of Hypertrophic Scars And Keloids. Systematic Reviews in Pharmacy, 12 (3), 115-120. doi:10.31838/srp.2021.3.20 |
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