Comparison Profile of Quality of Life, Phosphorylated-Tau, and Superoxide Dismutase Plasma in Women Elderly with and without Dementia

Abstract

Lisna Anisa Fitriana, Kusnandar Anggadiredja, Irma Darmawati, Lina Anisa Nasution, Linda Amalia, Slamet Rohaedi, Iwan Setiawan, Adang Suherman, I Ketut Adnyana

Accumulation of phosphorylated-tau and low levels of superoxide dismutase is associated with dementia affecting the quality of life in the elderly. This study aimed to determine differences in quality of life (QoL), phosphorylated-tau (pTAU), and superoxide dismutase (SOD) plasma in women elderly with and without dementia. The research method was a cross-sectional study. Examination of dementia using MMSE (Mini-Mental State Examination) and CDR (Clinical Dementia Rating Scale). The measure of the quality of life using the WHO-QoL questionnaire and plasma level of p-TAU and SOD using ELISA (Enzyme-linked Immunosorbent Assay). The research sample consisted of 70 women elderly mean aged 74.69 ± 9.27 years who lived in three nursing homes. Data analysis used fisher test, independent sample t-test, Mann-Whitney test, and linear regression test. The findings showed that the quality of life differed significantly in the domain of physic (p=0.001), social-relationship (p=0.002), psychological (p<0.001), environment (p<0.001), and plasma level of p-TAU (p=0.028) and SOD (p<0.001) in women elderly with and without dementia. In term of its association with dementia, p-TAU (p=0.001), SOD (p=0.003), MMSE (p=0.028), and QoL-social (p=0.176) were final model factors of dementia in women elderly. In conclusion, there are significant differences in quality of life, p-TAU, and plasma SOD between women elderly with and without dementia.