Correlation Between Serum Asprosin Level And Oxidative Stress In Iraqi Patients With Type Ii Diabetes Mellitus

Abstract

Mohammed Basim Ahmed Alobaidi and Rafah Razooq Hameed Al-Samarrai

Background: Asprosin, a new protein hormone identifies by USA researcher team in 2016, secreted by the white adipose tissue. Asprosin induce releasing of hepatic glucose, its pathologically increased in insulin resistant, obesity and diabetic mellitus.
Method: Cross sectional study were carried out to evaluate the concentration of serum asprosin, glucose, Total antioxidant capacity-TAC, malondialdehyde –MDA, Glutathione-S-transferase-GST and HbA1c for 121 sample of patients with type II diabetes mellitus (age between 25-45) collected from Specialized Center for Diabetes and Endocrinology / Baghdad-Alrasapha from 1/10/2019 to 20/12/2019. The groups of samples were divided into three groups, 1st group G1 include twenty four patients(12male and 12female) newly diagnose with type II diabetic mellitus without any treatment(new onset), 2nd group G2 include sixty nine(36male and 33female) patients with type II diabetic mellitus taken a treatment(old diagnostic cases) and twenty eight sample(12male and 16 female) for healthy individuals as control group-C.
Results:The results showed that the concentration of asprosin, glucose, HbA1c and MDA were significantly higher P≤0.05 in G2 as compared with control group, with no significant change P≤0.05 to the concentration of asprosin , glucose and MDA in G1 as compared with control group, while at the same group the concentration of HbA1c and GST significantly higher P≤0.05 comparing with C, The concentration of TAC significantly decreased P≤0.05 in G1 and G2 as comparing with control group.
Conclusion: The concentration of asprosin was increase in type II diabetic mellitus, this result associated with the complication of the disease.