Correlation Study of Betatrophein and GLP-1 with Some Biochemical Parameters in Iraqi Male Patients with Diabetic nephropathy (DN)

Abstract

Lamia S. Ashoor, Warka'a T. Saloum, Hassanain K. Al-Bairmani

Diabetes mellitus (DM) is one of complications which lead to Diabetic nephropathy (DN). Betatrophin is a hormone secreted by liver and affected lipid and glucose metabolism involving autophagy and adipogenesis. Betatrophin's role in glucose metabolism through regulation glucose level via insulin signaling pathway, glycogen synthesis in addition to inhibit gluconeogenesis. Glucagon-like peptide 1 (GLP-1) is a peptide hormone release from pancreatic α-cells, and intestinal L cells as responding to food intake. GLP-1 increases insulin secretion from pancreatic β-cells and decreases glycaemia through glucagon inhibition from pancreatic α-cells and deduction of satiety by delaying gastric evacuation. Also, GLP-1 decreases plasma glucose levels and maintains normal glycemia. This study was carried out to measure and compare Betatrophin and GLP-1 levels T2DM with DN in 45 Iraqi male patients and 37 control subjects. Betatrophin levels were high significant increase while GLP-1 levels were high significantly decreased compare to the healthy control. Conclusions: High level of betatrophin may be a good biomarker indicated in DN patients and more studies are needed to explain the metabolism of this biomarker in DN.