Crosstalk Between Sirt1 Activators And Nf-?b Axis As A Therapeutic Target To Reduce Pancreatic Cancer

Abstract

Marwah Saad Joudah, Inam Sameh Arif, Basma Talib Al-Sudani.

The cellular availability of NAD+ is essential for Sirtuin 1 (SIRT1), a class III histone deacetylase, catalytic activity which make it as a reliable metabolic sensor. For evidence, SIRT1 had a high expression in tissue with metabolic activity including muscle, brain, liver, pancreas, and adipose tissue. Previous reports have documented the crosstalk between SIRT1 and nuclear factor kappa-B (NF-κB) signaling in conditions such as lymphoma, leukemia, and myeloma. The purpose of present study is to find the relationships between SIRT1 and NF-κB activation on pancreatic cancer cells (Capan-2, AsPC-1, and BxPC-3). We found the activation of NF-κB was inhibited by use 1 µM SIRT1 aptamer by increased the activity of SIRT1 protein. Overall, our findings suggested that SIRT1 activation resulting in inhibition of pancreatic cancer cells growth and significantly repression of NF-κB proteins activation, this activation of SIRT1 by aptamer may be considered as a potential future therapy for cancer especially pancreatic cancer.

How to Cite this Article
Pubmed Style

Marwah Saad Joudah, Inam Sameh Arif, Basma Talib Al-Sudani. Crosstalk Between Sirt1 Activators And Nf-Κb Axis As A Therapeutic Target To Reduce Pancreatic Cancer. SRP. 2021; 12(3): 207-212. 
doi:10.31838/srp.2021.3.34

Web Style

Marwah Saad Joudah, Inam Sameh Arif, Basma Talib Al-Sudani. Crosstalk Between Sirt1 Activators And Nf-Κb Axis As A Therapeutic Target To Reduce Pancreatic Cancer. http://www.sysrevpharm.org/?mno=51635 [Access: March 30, 2021]. doi:10.31838/srp.2021.3.34

AMA (American Medical Association) Style

Marwah Saad Joudah, Inam Sameh Arif, Basma Talib Al-Sudani. Crosstalk Between Sirt1 Activators And Nf-Κb Axis As A Therapeutic Target To Reduce Pancreatic Cancer. SRP. 2021; 12(3): 207-212. doi:10.31838/srp.2021.3.34



Vancouver/ICMJE Style

Marwah Saad Joudah, Inam Sameh Arif, Basma Talib Al-Sudani. Crosstalk Between Sirt1 Activators And Nf-Κb Axis As A Therapeutic Target To Reduce Pancreatic Cancer. SRP. (2021), [cited March 30, 2021]; 12(3): 207-212. doi:10.31838/srp.2021.3.34



Harvard Style

Marwah Saad Joudah, Inam Sameh Arif, Basma Talib Al-Sudani (2021) Crosstalk Between Sirt1 Activators And Nf-Κb Axis As A Therapeutic Target To Reduce Pancreatic Cancer. SRP, 12 (3), 207-212. doi:10.31838/srp.2021.3.34



Turabian Style

Marwah Saad Joudah, Inam Sameh Arif, Basma Talib Al-Sudani. 2021. Crosstalk Between Sirt1 Activators And Nf-Κb Axis As A Therapeutic Target To Reduce Pancreatic Cancer. Systematic Reviews in Pharmacy, 12 (3), 207-212. doi:10.31838/srp.2021.3.34



Chicago Style

Marwah Saad Joudah, Inam Sameh Arif, Basma Talib Al-Sudani. "Crosstalk Between Sirt1 Activators And Nf-Κb Axis As A Therapeutic Target To Reduce Pancreatic Cancer." Systematic Reviews in Pharmacy 12 (2021), 207-212. doi:10.31838/srp.2021.3.34



MLA (The Modern Language Association) Style

Marwah Saad Joudah, Inam Sameh Arif, Basma Talib Al-Sudani. "Crosstalk Between Sirt1 Activators And Nf-Κb Axis As A Therapeutic Target To Reduce Pancreatic Cancer." Systematic Reviews in Pharmacy 12.3 (2021), 207-212. Print. doi:10.31838/srp.2021.3.34



APA (American Psychological Association) Style

Marwah Saad Joudah, Inam Sameh Arif, Basma Talib Al-Sudani (2021) Crosstalk Between Sirt1 Activators And Nf-Κb Axis As A Therapeutic Target To Reduce Pancreatic Cancer. Systematic Reviews in Pharmacy, 12 (3), 207-212. doi:10.31838/srp.2021.3.34

Most Viewed Articles
  • Dental Development between Assisted Reproductive Therapy (Art) and Natural Conceived Children: A Comparative Pilot Study Norzaiti Mohd Kenali, Naimah Hasanah Mohd Fathil, Norbasyirah Bohari, Ahmad Faisal Ismail, Roszaman Ramli SRP. 2020; 11(1): 01-06 » doi: 10.5530/srp.2020.1.01
  • Psychometric properties of the World Health Organization Quality of life instrument, short form: Validity in the Vietnamese healthcare context Trung Quang Vo*, Bao Tran Thuy Tran, Ngan Thuy Nguyen, Tram ThiHuyen Nguyen, Thuy Phan Chung Tran SRP. 2020; 11(1): 14-22 » doi: 10.5530/srp.2019.1.3
  • A Review of Pharmacoeconomics: the key to “Healthcare for All” Hasamnis AA, Patil SS, Shaik Imam, Narendiran K SRP. 2019; 10(1): s40-s42 » doi: 10.5530/srp.2019.1s.21
  • Deuterium Depleted Water as an Adjuvant in Treatment of Cancer Anton Syroeshkin, Olga Levitskaya, Elena Uspenskaya, Tatiana Pleteneva, Daria Romaykina, Daria Ermakova SRP. 2019; 10(1): 112-117 » doi: 10.5530/srp.2019.1.19
Most Downloaded
  • Dental Development between Assisted Reproductive Therapy (Art) and Natural Conceived Children: A Comparative Pilot Study Norzaiti Mohd Kenali, Naimah Hasanah Mohd Fathil, Norbasyirah Bohari, Ahmad Faisal Ismail, Roszaman Ramli SRP. 2020; 11(1): 01-06 » doi: 10.5530/srp.2020.1.01
  • Manilkara zapota (L.) Royen Fruit Peel: A Phytochemical and Pharmacological Review Karle Pravin P, Dhawale Shashikant C SRP. 2019; 10(1): 11-14 » doi: 0.5530/srp.2019.1.2
  • Pharmacognostic and Phytopharmacological Overview on Bombax ceiba Pankaj Haribhau Chaudhary, Mukund Ganeshrao Tawar SRP. 2019; 10(1): 20-25 » doi: 10.5530/srp.2019.1.4
  • A Review of Pharmacoeconomics: the key to “Healthcare for All” Hasamnis AA, Patil SS, Shaik Imam, Narendiran K SRP. 2019; 10(1): s40-s42 » doi: 10.5530/srp.2019.1s.21
  • A Prospective Review on Phyto-Pharmacological Aspects of Andrographis paniculata Govindraj Akilandeswari, Arumugam Vijaya Anand, Palanisamy Sampathkumar, Puthamohan Vinayaga Moorthi, Basavaraju Preethi SRP. 2019; 10(1): 15-19 » doi: 10.5530/srp.2019.1.3